Target Name: ZNF224
NCBI ID: G7767
Other Name(s): zinc finger protein 224 | Zinc finger 2, bone marrow | Zinc finger protein 27 | Zinc finger protein 255 | KOX22 | Zinc finger protein KOX22 | Zinc finger protein 233 | BMZF2 | ZNF27 | zinc finger protein 255 | ZN224_HUMAN | ZNF233 | Bone marrow zinc finger 2 | zinc finger protein 27 | bone marrow zinc finger 2 | zinc finger protein 233 | Zinc finger protein 224 | BMZF-2 | Zinc finger protein ZNF255 | zinc finger protein KOX22 | ZNF255 | Zinc finger protein 27 (KOX 22)

ZNF224: A Potential Drug Target and Biomarker

Zinc finger proteins (ZFPs) are a family of transcription factors, which play a crucial role in gene regulation and are involved in various cellular processes. ZNF224 is a specific ZFP that has gained significant attention due to its potential as a drug target or biomarker.

The ZNF224 gene is located on chromosome 6p21.2 and encodes a protein with 224 amino acid residues. ZNF224 is a key regulator of the microRNA (miRNA) pathway, which is a post-transcriptional regulatory network that plays a vital role in gene expression and cell development.

ZNF224 has been shown to have a direct impact on the miRNA pathway. It has been reported that ZNF224 can interact with several key players in the miRNA pathway, including miR-18a, miR-202, and miR-204. These interactions have been shown to alter the expression of target genes, suggesting that ZNF224 may be a valuable drug target or biomarker.

In addition to its impact on the miRNA pathway, ZNF224 has also been shown to play a role in cell signaling pathways. It has been reported to be involved in the regulation of cell adhesion, migration, and invasion, as well as in the regulation of cell survival.

The potential drug target status of ZNF224 is further supported by its function as a negative regulator of the TGF-β pathway. TGF-β is a well-known transcription factor that plays a crucial role in cell signaling and growth, and its activity is often disrupted in various diseases, including cancer.

Several studies have shown that ZNF224 can inhibit the activity of TGF-β, suggesting that it may be a potential TGF-β inhibitor. This property makes ZNF224 an attractive candidate for anti-tumor drug development.

In conclusion, ZNF224 is a ZFP that has gained significant attention due to its potential as a drug target or biomarker. Its interaction with key players in the miRNA pathway and its role in cell signaling pathways make it an attractive candidate for drug development. Additionally, Its ability to inhibit TGF-β activity further supports its potential as a TGF-β inhibitor. Further research is needed to fully understand the full potential of ZNF224 as a drug target or biomarker.

Protein Name: Zinc Finger Protein 224

Functions: May be involved in transcriptional regulation as a transcriptional repressor. The DEPDC1A-ZNF224 complex may play a critical role in bladder carcinogenesis by repressing the transcription of the A20 gene, leading to transport of NF-KB protein into the nucleus, resulting in suppression of apoptosis of bladder cancer cells

More Common Targets

ZNF225 | ZNF225-AS1 | ZNF226 | ZNF227 | ZNF229 | ZNF23 | ZNF230 | ZNF232 | ZNF232-AS1 | ZNF233 | ZNF234 | ZNF235 | ZNF236 | ZNF236-DT | ZNF239 | ZNF24 | ZNF248 | ZNF25 | ZNF250 | ZNF251 | ZNF252P | ZNF252P-AS1 | ZNF253 | ZNF254 | ZNF256 | ZNF257 | ZNF26 | ZNF260 | ZNF263 | ZNF264 | ZNF266 | ZNF267 | ZNF268 | ZNF271P | ZNF273 | ZNF274 | ZNF275 | ZNF276 | ZNF277 | ZNF28 | ZNF280A | ZNF280B | ZNF280C | ZNF280D | ZNF281 | ZNF282 | ZNF283 | ZNF284 | ZNF285 | ZNF285CP | ZNF286A | ZNF286B | ZNF287 | ZNF292 | ZNF295-AS1 | ZNF296 | ZNF3 | ZNF30 | ZNF300 | ZNF300P1 | ZNF302 | ZNF304 | ZNF311 | ZNF316 | ZNF317 | ZNF318 | ZNF319 | ZNF32 | ZNF32-AS1 | ZNF32-AS2 | ZNF32-AS3 | ZNF320 | ZNF321P | ZNF322 | ZNF322P1 | ZNF324 | ZNF324B | ZNF326 | ZNF329 | ZNF330 | ZNF331 | ZNF333 | ZNF334 | ZNF335 | ZNF337 | ZNF33A | ZNF33B | ZNF33BP1 | ZNF34 | ZNF341 | ZNF341-AS1 | ZNF343 | ZNF345 | ZNF346 | ZNF347 | ZNF35 | ZNF350 | ZNF350-AS1 | ZNF354A | ZNF354B