Target Name: ZNF354A
NCBI ID: G6940
Other Name(s): EZNF | epididymis luminal protein 104 | KID1 | TCF17 | KID-1 | HEL104 | zinc finger protein 354A | Zinc finger protein 354A (isoform 1) | Zinc finger protein 354A, transcript variant 1 | Zinc finger protein eZNF | Zinc finger protein 354A | ZNF354A variant 1 | Z354A_HUMAN | zinc finger protein eZNF | Transcription factor 17 | transcription factor 17 | HKL1 | TCF-17

ZNF354A: A Potential Drug Target and Biomarker

Introduction

ZNF354A, also known as EZNF, is a non-coding RNA molecule that plays a crucial role in the regulation of various cellular processes. It is a key component of the ZNF3 complex, which is a highly conserved trans-regulatory network that regulates the expression of genes in many tissues and organs. ZNF354A has been identified as a potential drug target and biomarker due to its unique structure, function, and involvement in several diseases.

Structure and Function

ZNF354A is a small non-coding RNA molecule that contains 23 amino acid residues. It has a characteristic stem-loop structure and a 5'-end that is rich in conserved conserved amino acid sequence. ZNF354A functions as a transcriptional regulator by binding to specific DNA sequences and regulating gene expression levels.

ZNF354A is a key component of the ZNF3 complex, which is a highly conserved trans-regulatory network that regulates the expression of genes in many tissues and organs. The ZNF3 complex consists of three subunits: ZNF3, ZNF4, and ZNF5. ZNF3 and ZNF4 are involved in the formation of the complex, while ZNF5 appears to play a more unique role in the regulation of gene expression. ZNF354A is located between ZNF5 and ZNF4 and is in close proximity to both subunits.

The ZNF3 complex plays a crucial role in the regulation of various cellular processes, including cell growth, differentiation, and inflammation. Many diseases are associated with disruptions in the regulation of gene expression by the ZNF3 complex. For example, mutations in the ZNF3 gene have has been linked to a variety of diseases, including neurodevelopmental disorders, cancer, and autoimmune diseases.

Potential Drug Target

The ZNF354A protein has been identified as a potential drug target due to its unique structure and function. The ZNF354A protein is involved in the regulation of cellular processes that are crucial for the development and maintenance of cancer. For example, ZNF354A has been shown to play a role in the regulation of cell cycle progression, which is a critical step in the development of cancer.

In addition, ZNF354A has been shown to play a role in the regulation of angiogenesis, which is the process by which new blood vessels are formed. Angiogenesis is a critical process for the development of cancer, and ZNF354A has been shown to regulate the formation of new blood vessels in tumors.

Biomarker

The ZNF354A protein has also been identified as a potential biomarker for several diseases. For example, ZNF354A has been shown to be downregulated in various diseases, including neurodevelopmental disorders, cancer, and autoimmune diseases. Additionally, ZNF354A has been shown to be involved in the regulation of cellular processes that are crucial for the development and maintenance of these diseases.

Conclusion

ZNF354A is a non-coding RNA molecule that plays a crucial role in the regulation of various cellular processes. It is a key component of the ZNF3 complex and has been shown to be involved in the regulation of cell cycle progression, angiogenesis, and the development and maintenance of various diseases. Given its unique structure and function, ZNF354A is a potential drug target and biomarker. Further research is needed to fully understand the role of ZNF354A in the regulation of cellular processes and its potential as a drug.

Protein Name: Zinc Finger Protein 354A

More Common Targets

ZNF354B | ZNF354C | ZNF355P | ZNF358 | ZNF362 | ZNF365 | ZNF366 | ZNF367 | ZNF37A | ZNF37BP | ZNF382 | ZNF383 | ZNF384 | ZNF385A | ZNF385B | ZNF385C | ZNF385D | ZNF385D-AS1 | ZNF385D-AS2 | ZNF391 | ZNF394 | ZNF395 | ZNF396 | ZNF397 | ZNF398 | ZNF402P | ZNF404 | ZNF407 | ZNF407-AS1 | ZNF408 | ZNF41 | ZNF410 | ZNF414 | ZNF415 | ZNF416 | ZNF417 | ZNF418 | ZNF419 | ZNF420 | ZNF423 | ZNF425 | ZNF426 | ZNF428 | ZNF429 | ZNF43 | ZNF430 | ZNF431 | ZNF432 | ZNF433 | ZNF433-AS1 | ZNF436 | ZNF436-AS1 | ZNF438 | ZNF439 | ZNF44 | ZNF440 | ZNF441 | ZNF442 | ZNF443 | ZNF444 | ZNF445 | ZNF446 | ZNF449 | ZNF45 | ZNF451 | ZNF454 | ZNF460 | ZNF461 | ZNF462 | ZNF467 | ZNF468 | ZNF469 | ZNF470 | ZNF471 | ZNF473 | ZNF473CR | ZNF479 | ZNF48 | ZNF480 | ZNF483 | ZNF484 | ZNF485 | ZNF486 | ZNF487 | ZNF488 | ZNF490 | ZNF491 | ZNF492 | ZNF493 | ZNF496 | ZNF497 | ZNF497-AS1 | ZNF500 | ZNF501 | ZNF502 | ZNF503 | ZNF503-AS1 | ZNF503-AS2 | ZNF506 | ZNF507