Target Name: ZNF428
NCBI ID: G126299
Other Name(s): Zfp428 | enzyme-like protein PIT13 | zinc finger protein 428 | ZN428_HUMAN | Enzyme-like protein PIT13 | Zinc finger protein 428 | C19orf37

ZNF428: A Potential Drug Target and Biomarker

ZNF428 (Zinc Finger Nucleotide-conjugated G protein-coupled receptor 428) is a non-coding RNA molecule that plays a crucial role in various cellular processes. It is a member of the ZNF gene family, which is known for its involvement in various signaling pathways, including cell growth, differentiation, and inflammation. ZNF428 is expressed in many tissues and cell types, including brain, pancreas, and peripheral tissues.

Gene Structure and Expression

The ZNF gene is located on chromosome 6p21.1 and encodes a 218-amino acid protein with a molecular weight of approximately 60 kDa. The protein consists of a N-terminal transmembrane domain, a coiled-coil region, and a C-terminal cytoplasmic domain. ZNF428 is a splicing variant of the ZNF gene, with several splice variants identified in the literature. The expression of ZNF428 is highly tissue-specific, with different levels of expression observed in various tissues and cell types.

Function and Interaction

ZNF428 is a protein that can modulate the activity of various intracellular signaling pathways, including the TGF-灏? pathway. TGF-灏? is a well-established signaling pathway that plays a crucial role in cell growth, differentiation, and inflammation. The TGF-灏? pathway is activated by various growth factors, including transforming growth factor-beta (TGF-灏?), which promotes cell proliferation and survival by regulating cell signaling pathways. ZNF428 has been shown to regulate the activity of the TGF-灏? pathway by interacting with the protein Smad.

Smad signaling is a highly conserved signaling pathway that is involved in various cellular processes, including cell growth, differentiation, and inflammation. The Smad protein is a transcription factor that can interact with various DNA-binding sequences to regulate gene expression. ZNF428 has been shown to interact with the Smad protein, which may contribute to its modulation of the TGF-灏? pathway.

Drug Targeting and Biomarker

The potential drug targeting of ZNF428 is based on its involvement in the TGF-灏? pathway. Several studies have shown that inhibitors of the TGF-灏? pathway can be effective in treating various diseases, including cancer, neurodegenerative diseases, and autoimmune diseases. ZNF428 is a potential drug target because its regulation of the TGF-灏? pathway suggests that it may be involved in the pathophysiology of various diseases.

In addition to its potential drug targeting, ZNF428 has also been identified as a potential biomarker for several diseases. The TGF-灏? pathway is involved in various biological processes, including cell growth, differentiation, and inflammation, and is a potential target for various biomarkers. ZNF428 has been shown to be expressed in various diseases, including cancer, neurodegenerative diseases, and autoimmune diseases. Therefore, its levels may be a potential biomarker for these diseases.

Conclusion

ZNF428 is a non-coding RNA molecule that plays a crucial role in various cellular processes, including the regulation of the TGF-灏? pathway. Its regulation of the TGF-灏? pathway suggests that it may be involved in the pathophysiology of various diseases. In addition to its potential drug targeting and biomarker potential, ZNF428 is a potential target for further research into the molecular mechanisms underlying its function in disease.

Protein Name: Zinc Finger Protein 428

More Common Targets

ZNF429 | ZNF43 | ZNF430 | ZNF431 | ZNF432 | ZNF433 | ZNF433-AS1 | ZNF436 | ZNF436-AS1 | ZNF438 | ZNF439 | ZNF44 | ZNF440 | ZNF441 | ZNF442 | ZNF443 | ZNF444 | ZNF445 | ZNF446 | ZNF449 | ZNF45 | ZNF451 | ZNF454 | ZNF460 | ZNF461 | ZNF462 | ZNF467 | ZNF468 | ZNF469 | ZNF470 | ZNF471 | ZNF473 | ZNF473CR | ZNF479 | ZNF48 | ZNF480 | ZNF483 | ZNF484 | ZNF485 | ZNF486 | ZNF487 | ZNF488 | ZNF490 | ZNF491 | ZNF492 | ZNF493 | ZNF496 | ZNF497 | ZNF497-AS1 | ZNF500 | ZNF501 | ZNF502 | ZNF503 | ZNF503-AS1 | ZNF503-AS2 | ZNF506 | ZNF507 | ZNF510 | ZNF511 | ZNF512 | ZNF512B | ZNF513 | ZNF514 | ZNF516 | ZNF516-DT | ZNF517 | ZNF518A | ZNF518B | ZNF519 | ZNF519P3 | ZNF521 | ZNF524 | ZNF525 | ZNF526 | ZNF527 | ZNF528 | ZNF528-AS1 | ZNF529 | ZNF529-AS1 | ZNF530 | ZNF532 | ZNF534 | ZNF536 | ZNF540 | ZNF541 | ZNF542P | ZNF543 | ZNF544 | ZNF546 | ZNF547 | ZNF548 | ZNF549 | ZNF550 | ZNF551 | ZNF552 | ZNF554 | ZNF555 | ZNF556 | ZNF557 | ZNF558