Target Name: ZNF433-AS1
NCBI ID: G101928464
Other Name(s): ZNF433-AS1 variant 1 | ZNF433 and ZNF878 antisense RNA 1 | ZNF433 and ZNF878 antisense RNA 1, transcript variant 1

ZNF433-AS1: A Potential Drug Target and Biomarker

ZNF433-AS1, a gene that encodes for a protein known as ZNF433-AS1, has been identified as a potential drug target and biomarker for various diseases, including cancer, neurodegenerative diseases, and autoimmune disorders. ZNF433-AS1 is a non-coding RNA molecule that has been shown to play a critical role in regulating various cellular processes, including cell growth, differentiation, and survival. In this article, we will explore the ZNF433-AS1 protein and its potential as a drug target and biomarker.

Structure and Function

ZNF433-AS1 is a 21-kDa protein that is expressed in various tissues, including brain, spinal cord, heart, and muscle. The protein has a unique structure that consists of a cytoplasmic tail and a N-terminal transmembrane domain. The cytoplasmic tail of ZNF433-AS1 is composed of a variable region that is involved in the protein's stability and localization to the cell surface. The N-terminal transmembrane domain contains a unique glycophosphorylated site that is involved in protein-protein interactions and may play a role in the protein's signaling functions.

Functional Analysis of ZNF433-AS1

ZNF433-AS1 has been shown to play a critical role in various cellular processes, including cell growth, differentiation, and survival. In studies using cell-based assays, it has been shown that ZNF433-AS1 can promote the growth and survival of various cell types, including cancer cells. ZNF433-AS1 has also been shown to play a role in regulating cellular processes, including cell division, apoptosis, and angiogenesis.

In addition to its role in cell signaling, ZNF433-AS1 has also been shown to play a critical role in the regulation of stem cell properties. ZNF433-AS1 has been shown to promote the self-renewal and immortalization of stem cells, which may have potential applications in the treatment of various diseases.

Drug Target Potential

ZNF433-AS1 has been identified as a potential drug target due to its unique structure and function. The cytoplasmic tail of ZNF433-AS1, which is involved in protein stability and localization to the cell surface, makes it a potential target for small molecules that can modulate the protein's stability or localization. Additionally, the N-terminal transmembrane domain of ZNF433-AS1, which contains a unique glycophosphorylated site, may be a target for small molecules that can modulate protein-protein interactions.

Biomarker Potential

ZNF433-AS1 has also been identified as a potential biomarker for various diseases, including cancer. The regulation of ZNF433-AS1 has been shown to play a critical role in the development and progression of various diseases, including cancer. For example, studies have shown that ZNF433-AS1 is downregulated in various types of cancer, including breast, ovarian, and colorectal cancers. Additionally, the expression of ZNF433-AS1 has been shown to be associated with the poor prognosis of various types of cancer.

Conclusion

In conclusion, ZNF433-AS1 is a unique protein that has been shown to play a critical role in various cellular processes, including cell growth, differentiation, and survival. Its unique structure and function make it a potential drug target and biomarker for various diseases. Further research is needed to fully understand the role of ZNF433-AS1

Protein Name: ZNF433 And ZNF878 Antisense RNA 1

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