Methyltransferase-like Protein 22 (METTL22) as A Drug Target for Various Diseases

Target Name: METTL22

NCBI ID: G79091

Methyltransferase-like Protein 22 (METTL22) as A Drug Target for Various Diseases

Methyltransferase-like protein 22 (METTL22) is a protein that is expressed in various tissues throughout the body. It is a key player in the epigenetic regulation of gene expression, where methylation of the promoter region of a gene can repress its translation into protein. METTL22 is a non-coding RNA molecule that functions as a scaffold to recruit chromatin modifiers and enzymes for DNA methylation.

METTL22 is a 22-kDa protein that consists of 192 amino acid residues. It has a characteristic Rossmann-fold that is commonly found in proteins that play a role in protein-protein interactions. The Rossmann-fold is a structural motif that is composed of a specific sequence of amino acids that forms an imidazole ring. This motif allows METTL22 to form a stable complex with other proteins that have a similar domain.

One of the unique features of METTL22 is its ability to interact with DNA methyltransferases (DNMTs). DNMTs are enzymes that remove methyl groups from the promoter region of a gene, thereby repressing its translation into protein. METTL22 has been shown to interact with DNMTs such as HDACs (hairless and deduced DNA-binding proteins) and HDACs that are involved in the epigenetic regulation of gene expression.

In addition to its interaction with DNMTs, METTL22 has also been shown to interact with other proteins involved in the epigenetic regulation of gene expression, such as histone modifiers and transcriptional factors. METTL22 has been shown to physically interact with the histone methylator HDACs (histone- modifying enzymes) to recruit these enzymes to the DNA promoter.

METTL22 is also involved in the regulation of microRNA (miRNA) expression. MiRNA are small non-coding RNAs that play a role in post-transcriptional gene regulation by binding to specific target RNAs. METTL22 has been shown to interact with the miRNA target RNA- protein interactions, which may contribute to the regulation of miRNA expression.

METTL22 has also been shown to play a role in the regulation of gene expression in various cell types. For example, METTL22 has been shown to be involved in the regulation of gene expression in the brain, where it has been shown to play a role in the development and maintenance of neuronal stem cells.

In addition to its role in the regulation of gene expression, METTL22 has also been shown to have potential as a drug target. Several studies have shown that METTL22 can be targeted by small molecules, such as inhibitors of HDACs and DNA methylation enzymes. In addition , METTL22 has been shown to have a high degree of cross-talk with other proteins, including HDACs, which may make it difficult to target METTL22 effectively.

In conclusion, METTL22 is a protein that is involved in the regulation of various gene expression processes in the cell. Its ability to interact with DNA methyltransferases and other proteins involved in the epigenetic regulation of gene expression makes it an attractive drug target. Furthermore, METTL22's role in the regulation of microRNA expression and the regulation of neuronal stem cells make it a promising target for the development of new treatments for various neurological and psychiatric disorders.

Overall, METTL22 is a protein that has the potential to be a drug target for various diseases. Further research is needed to fully understand its role in the regulation of gene expression and its potential as a therapeutic agent.

Protein Name: Methyltransferase 22, Kin17 Lysine

Functions: Protein N-lysine methyltransferase. Trimethylates KIN at Lys-135 (in vitro)

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