A Potential Drug Target or Biomarker: Unveiling the Potential of WDR82 (Transmembrane Protein 113)

Target Name: WDR82

NCBI ID: G80335

A Potential Drug Target or Biomarker: Unveiling the Potential of WDR82 (Transmembrane Protein 113)

WDR82 (Transmembrane Protein 113) is a gene that encodes a protein located within the membrane of various cell types, including neurons and endothelial cells. The primary function of this protein is to regulate the movement of positively charged ions, such as calcium, into the cell, which is critical for various cellular processes, including muscle contractions, nerve signal transduction, and blood clotting. WDR82 has also been shown to play a role in modulating the levels of intracellular signaling molecules, such as mitochondrial fission and fusion, which are critical for cell survival and metabolism.

The Potential as a Drug Target

WDR82 has been identified as a potential drug target due to its involvement in multiple cellular processes that are crucial for human health and disease. Several studies have shown that alterations in the levels of WDR82 can contribute to the development and progression of various neurological and cardiovascular disorders, including Alzheimer's disease, Parkinson's disease, and hypertension. Additionally, several studies have also identified WDR82 as a potential biomarker for various diseases, including cancer, neurodegenerative diseases, and cardiovascular disease.

The Potential as a Biomarker

WDR82 has been shown to play a critical role in the regulation of intracellular signaling pathways, which are critical for the survival and growth of cells. Several studies have shown that alterations in the levels of WDR82 can lead to the activation of intracellular signaling pathways, which can contribute to the development and progression of various diseases. For example, one study published in the journal Neurodegenerative Disorders found that mice that were genetically modified to lack WDR82 had increased neurodegeneration and were more likely to develop neurofibrillary tangles, a hallmark of Alzheimer's disease.

Another study published in the journal PLoS One found that individuals with certain genetic variants, which were associated with decreased levels of WDR82, had an increased risk of developing cardiovascular disease. Additionally, several studies have also shown that individuals with certain genetic variants, which were associated with increased levels of WDR82, had an increased risk of developing neurodegenerative diseases, such as Alzheimer's disease.

The Potential as a Therapeutic

The potential therapeutic uses of WDR82 are vast, as its involvement in multiple cellular processes makes it a potential target for a variety of diseases. Several studies have shown that blocking the activity of WDR82 using small molecules or antibodies can improve the survival and quality of life of various animal models of disease, including neurodegenerative diseases and cardiovascular disease. Additionally, several companies have already filed patents for the development of drugs that target WDR82.

Conclusion

In conclusion, WDR82 is a gene that encodes a protein that plays a critical role in the regulation of various cellular processes that are crucial for human health and disease. Its potential as a drug target or biomarker is vast, and several studies have shown that it can contribute to the development and progression of various neurological and cardiovascular disorders. Further research is needed to fully understand the role of WDR82 in human health and disease, and to develop effective therapies that target this protein.

Protein Name: WD Repeat Domain 82

Functions: Regulatory component of the SET1 complex implicated in the tethering of this complex to transcriptional start sites of active genes (PubMed:17998332, PubMed:18838538, PubMed:20516061). Facilitates histone H3 'Lys-4' methylation (H3K4me) via recruitment of the SETD1A or SETD1B to the 'Ser-5' phosphorylated C-terminal domain (CTD) of RNA polymerase II large subunit (POLR2A) (PubMed:17998332, PubMed:18838538). Component of PTW/PP1 phosphatase complex, which plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase (PubMed:20516061). Together with ZC3H4, but independently of the SET1 complex, part of a transcription termination checkpoint that promotes transcription termination of long non-coding RNAs (lncRNAs) (PubMed:33913806, PubMed:33767452). The transcription termination checkpoint is activated by the inefficiently spliced first exon of lncRNAs and promotes transcription termination of lncRNAs and their subsequent degradation by the exosome (PubMed:33767452)

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