KRTAP9-9: A Potential Drug Target and Biomarker (G81870)

Target Name: KRTAP9-9

NCBI ID: G81870

KRTAP9-9: A Potential Drug Target and Biomarker

Keratin-associated protein 9-5 (KRTAP9-9) is a protein that has been identified as a potential drug target and biomarker for various diseases, including cancer. Its unique structure and function have made it an attractive target for researchers to investigate.

The protein KRTAP9-9 is a member of the keratin family, which is known for their role in the development and maintenance of hair and nails. KRTAP9-9 is expressed in a variety of tissues, including skin, scalp, and hair, and has been shown to play a role in regulating cell growth and differentiation.

One of the key features of KRTAP9-9 is its ability to interact with various signaling pathways. It has been shown to play a role in the JAK/STAT signaling pathway, which is involved in the regulation of cell growth and survival. Additionally, KRTAP9-9 has been shown to interact with the TGF-β pathway, which is involved in the regulation of cell growth and differentiation.

These interactions between KRTAP9-9 and signaling pathways have led to its potential as a drug target. By targeting KRTAP9-9 with small molecules or antibodies, researchers may be able to disrupt its activity and reduce the growth or progression of cancer cells.

In addition to its potential as a drug target, KRTAP9-9 has also been shown to be a potential biomarker for various diseases. Its expression has been shown to be elevated in a variety of cancer types, including breast, ovarian, and prostate cancer. Additionally, KRTAP9-9 has been shown to be associated with poor prognosis in cancer patients.

These findings make KRTAP9-9 an attractive candidate for further research as a potential drug target and biomarker. By investigating its effects on cancer cell growth and behavior, researchers may be able to develop new treatments for a variety of diseases.

Protein Name: Keratin Associated Protein 9-9

Functions: In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins

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