Understanding The Role of LARGE1 in Cellular Processes (G9215)

Target Name: LARGE1

NCBI ID: G9215

Understanding The Role of LARGE1 in Cellular Processes

LARGE1 (Acetyl-Glucosaminyl Transferase-Like 1A) is a gene that encodes a protein known as LGT1A. LGT1A is a member of the glycosaminoglycan (GAG) family, which is a type of carbohydrate that is found in the extracellular matrix (ECM) of many cells. The ECM is a complex mixture of carbohydrates, proteins, and nucleic acids that is involved in many cellular processes, including cell signaling, adhesion, and migration.

LARGE1 is a gene that has been implicated in a number of cellular processes, including the regulation of cell signaling, cell adhesion, and the development of cancer. The LGT1A protein is involved in the transfer of acetyl groups to the N-acetyl groups of various carbohydrates, including Glucosaminyl (GlcN) and Galectin. These acetyl groups are important for the maintenance of the positive charge on the surface of cells, which is critical for many cellular functions, including cell signaling and adhesion.

In addition to its role in cell signaling and adhesion, LARGE1 is also involved in the regulation of cancer cell growth and the development of cancer. For example, studies have shown that LARGE1 is involved in the development of various types of cancer, including lung cancer, breast cancer, and colon cancer. In addition, LARGE1 has also been shown to be involved in the regulation of cell cycle progression, and in the development of chromosomal abnormalities such as leukemia.

Due to its involvement in a number of cellular processes, LARGE1 has potential as a drug target or biomarker. For example, studies have shown that LARGE1 is involved in the regulation of cell signaling, and that it is a target for several different drugs, including inhibitors of the protein kinase B (PKB), a protein that is involved in many cellular processes, including cell signaling and the regulation of cell cycle progression. In addition, LARGE1 has also been shown to be involved in the regulation of cell adhesion, and that it is a target for adhesion molecules such as cadherins and immunoglobulin-like cell adhesion molecules (Ig-CAMs).

In conclusion, LARGE1 is a gene that has been implicated in a number of cellular processes, including the regulation of cell signaling, cell adhesion, and the development of cancer. Its involvement in these processes makes it a potential drug target or biomarker, and its potential as a drug target is further supported by its involvement in the regulation of PKB, a protein that is involved in many cellular processes, including cell signaling and the regulation of cell cycle progression. Further research is needed to fully understand the role of LARGE1 in cellular processes and its potential as a drug target or biomarker.

Protein Name: LARGE Xylosyl- And Glucuronyltransferase 1

Functions: Bifunctional glycosyltransferase with both alpha-1,3-xylosyltransferase and beta-1,3-glucuronyltransferase activities involved in the maturation of alpha-dystroglycan (DAG1) by glycosylation leading to DAG1 binding to laminin G-like domain-containing extracellular proteins with high affinity (PubMed:22223806, PubMed:15752776, PubMed:15661757, PubMed:25279699, PubMed:25279697, PubMed:23125099, PubMed:21987822). Elongates the glucuronyl-beta-1,4-xylose-beta disaccharide primer structure initiated by B4GAT1 by adding repeating units [-3-Xylose-alpha-1,3-GlcA-beta-1-] to produce a heteropolysaccharide (PubMed:22223806, PubMed:25279699, PubMed:25279697, PubMed:25138275, PubMed:32975514, PubMed:23125099). Requires the phosphorylation of core M3 (O-mannosyl trisaccharide) by POMK to elongate the glucuronyl-beta-1,4-xylose-beta disaccharide primer (PubMed:21987822). Plays a key role in skeletal muscle function and regeneration (By similarity)

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