TMEM187: A Potential Drug Target and Biomarker for Human Chronic Pain

Target Name: TMEM187

NCBI ID: G8269

TMEM187: A Potential Drug Target and Biomarker for Human Chronic Pain

Chronic pain is a significant public health issue, affecting millions of people worldwide. The World Health Organization (WHO) estimates that approximately 50 million adults experience chronic pain, with 20% of the global population affected. Chronic pain can be caused by various conditions, including musculoskeletal disorders, neuropathies, and psychosomatic conditions. The management of chronic pain is often challenging, and current treatments are often limited in their effectiveness and potential for long-term improvement.

TMEM187 is a protein that is expressed in various tissues of the human body, including the brain, spleen, and peripheral tissues. It is a member of the transmembrane protein (TM) family, which includes several other well-known proteins, including the pain receptor, TRPV1. TMEM187 has been shown to play a role in pain signaling and has potential as a drug target or biomarker for human chronic pain.

The Discovery of TMEM187 as a Drug Target

TMEM187 has been identified as a potential drug target for chronic pain due to its involvement in pain signaling. TMEM187 is known to be involved in the production of pain-related neurotransmitters, such as serotonin and norepinephrine, which are involved in the modulation of pain perception.

Studies have shown that TMEM187 is involved in the regulation of pain signaling in various tissues, including the brain, spinal cord, and peripheral tissues. For instance, TMEM187 has been shown to be involved in the modulation of pain sensitivity in neurotoxin-induced pain in rats. Additionally, TMEM187 has been shown to play a role in the regulation of pain modulation in inflammatory pain in mice.

The Potential of TMEM187 as a Biomarker for Chronic Pain

TMEM187 may also have potential as a biomarker for human chronic pain due to its expression and regulation in various tissues. The expression of TMEM187 has been shown to be affected by various factors, including pain modulation, neuroinflammation, and aging.

Studies have shown that TMEM187 levels are affected by various pain modalities, including thermal, chemical, and mechanical pain. For instance, TMEM187 levels are known to be elevated in response to thermal pain, and lower in response to chemical pain. Additionally, TMEM187 levels have been shown to be elevated in response to mechanical pain, such as muscle injury or inflammation.

TMEM187 levels may also be affected by neuroinflammation, as has been shown in several studies. For instance, TMEM187 has been shown to be involved in the regulation of pain modulation in neuroinflammation-induced pain in mice. Additionally, TMEM187 has been shown to be involved in the regulation of pain modulation in rheumatoid arthritis (RA) pain in humans.

Conclusion

TMEM187 is a protein that has been shown to play a role in pain signaling and has potential as a drug target or biomarker for human chronic pain. The modulation of pain sensitivity by TMEM187 may be involved in the regulation of various pain modalities, including thermal, chemical, and mechanical pain, as well as neuroinflammation. Further research is needed to fully understand the role of TMEM187 in pain signaling and its potential as a drug target or biomarker for human chronic pain.

Protein Name: Transmembrane Protein 187

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