TNFSF11: A Protein Involved in T-cell Receptor and Cell Growth

Target Name: TNFSF11

NCBI ID: G8600

TNFSF11: A Protein Involved in T-cell Receptor and Cell Growth

TNFSF11, also known as Tumor necrosis factor ligand superfamily member 11, is a protein that is expressed in a variety of tissues throughout the body, including the liver, spleen, and peripheral blood cells. It is a member of the TNFSF11 family, which is a group of proteins that are known as ligands for the T-cell receptor, a protein that is important for the development and function of T cells, a type of white blood cell that plays a critical role in the immune system.

The TNFSF11 protein is made up of 224 amino acid residues and has a calculated molecular weight of 24.1 kDa. It is found in a variety of tissues throughout the body, including the liver, spleen, and peripheral blood cells. It is expressed in high levels in the liver and spleen and has been shown to be involved in the immune response, as well as in the regulation of cell growth and differentiation.

One of the key functions of TNFSF11 is its role as a ligand for the T-cell receptor. The T-cell receptor is a protein that is found on the surface of T cells and is important for the development and function of these cells. The T-cell receptor is composed of a variable region and a constant region, and it is responsible for recognizing and responding to different types of molecules, including viruses and cancer cells.

TNFSF11 is thought to be involved in the regulation of the T-cell receptor by providing a signal for the receptor to initiate an immune response. It is also involved in the regulation of cell growth and differentiation, as well as in the regulation of inflammation.

In addition to its role as a ligand for the T-cell receptor, TNFSF11 is also thought to be involved in the regulation of other immune cells and tissues. For example, it has been shown to be involved in the regulation of the activity of natural killer cells, which are a type of immune cell that play a critical role in destroying cancer cells. It is also thought to be involved in the regulation of the activity of T-cells, which are a type of immune cell that play a critical role in the immune response.

TNFSF11 is also thought to be involved in the regulation of the immune response by providing a signal for the T-cell receptor to initiate an immune response. It is also involved in the regulation of cell growth and differentiation, as well as in the regulation of inflammation.

In conclusion, TNFSF11 is a protein that is expressed in a variety of tissues throughout the body and is involved in a number of important functions, including its role as a ligand for the T-cell receptor and its involvement in the regulation of cell growth and differentiation, as well as the immune response. As a result, it is a potential drug target and could be useful as a biomarker for the diagnosis and treatment of a variety of diseases.

Protein Name: TNF Superfamily Member 11

Functions: Cytokine that binds to TNFRSF11B/OPG and to TNFRSF11A/RANK. Osteoclast differentiation and activation factor. Augments the ability of dendritic cells to stimulate naive T-cell proliferation. May be an important regulator of interactions between T-cells and dendritic cells and may play a role in the regulation of the T-cell-dependent immune response. May also play an important role in enhanced bone-resorption in humoral hypercalcemia of malignancy (PubMed:22664871). Induces osteoclastogenesis by activating multiple signaling pathways in osteoclast precursor cells, chief among which is induction of long lasting oscillations in the intracellular concentration of Ca (2+) resulting in the activation of NFATC1, which translocates to the nucleus and induces osteoclast-specific gene transcription to allow differentiation of osteoclasts. During osteoclast differentiation, in a TMEM64 and ATP2A2-dependent manner induces activation of CREB1 and mitochondrial ROS generation necessary for proper osteoclast generation (By similarity)

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