Target Name: CCRL2
NCBI ID: G9034
Other Name(s): C-C motif chemokine receptor like 2, transcript variant 1 | CCRL2_HUMAN | C-C motif chemokine receptor like 2 | CRAM | putative MCP-1 chemokine receptor | HCR | CRAM-A | Chemokine receptor CCR11 | C-C chemokine receptor-like 2 (isoform 1) | CCRL2 variant 1 | Chemokine receptor X | C-C chemokine receptor-like 2 | chemokine receptor X | CKRX | CRAM-B | chemokine (C-C motif) receptor-like 2 | ACKR5 | atypical chemokine receptor 5 | chemokine receptor CCR11 | Chemokine (C-C motif) receptor-like 2 | Putative MCP-1 chemokine receptor

CCRL2 Receptor: A Potential Drug Target and Biomarker

The C-C motif chemokine receptor like 2 (CCRL2) is a G protein-coupled receptor that plays an important role in the regulation of immune responses and inflammation. The CCRL2 receptor is involved in the intracellular signaling pathways that coordinate the activities of many different signaling pathways, including the T cell signaling pathway.

The CCRL2 receptor is a transmembrane protein that is composed of an extracellular domain, a transmembrane domain, and an intracellular domain. The extracellular domain of the CCRL2 receptor is involved in the formation of the receptor complex with the protein G protein-coupled receptor serine kinase (GPCR) G伪118, which is a key regulator of the CCRL2 receptor.

The transmembrane domain of the CCRL2 receptor is involved in the regulation of the signaling pathway. This domain contains a unique structurally conserved region that is known as the \" chemokine receptor-like\" domain. This domain is involved in the recognition of the chemokine molecule, which is a small protein that is released by the immune cells in response to the presence of an pathogen or an antigen.

The intracellular domain of the CCRL2 receptor is involved in the regulation of the signaling pathway. This domain contains several conserved amino acids that are involved in the regulation of the signaling pathway.

Drug Targeting

The CCRL2 receptor is a potential drug target because of its involvement in the regulation of the immune response and inflammation. Several studies have shown that inhibitors of the CCRL2 receptor have been effective in treating various diseases, including cancer, autoimmune diseases, and neurodegenerative diseases.

One of the main advantages of targeting the CCRL2 receptor is the ability to specifically inhibit the signaling pathway that is involved in the regulation of the immune response and inflammation. This can lead to a more effective treatment of the disease and a reduced risk of side effects.

Another advantage of targeting the CCRL2 receptor is the ability to selectively target the receptor without affecting other proteins. This can help to reduce the risk of unintended side effects and improve the overall safety of the drug.

Biomarker

The CCRL2 receptor is also a potential biomarker for the diagnosis and monitoring of various diseases. The CCRL2 receptor is involved in the regulation of the immune response and inflammation, which can be used as a biomarker for the diagnosis and monitoring of autoimmune diseases, cancer, and neurodegenerative diseases.

Conclusion

The CCRL2 receptor is a G protein-coupled receptor that is involved in the regulation of the immune response and inflammation. It is a potential drug target and a potential biomarker for the diagnosis and monitoring of various diseases. Further research is needed to fully understand the role of the CCRL2 receptor and its potential as a drug target and biomarker.

Protein Name: C-C Motif Chemokine Receptor Like 2

Functions: Receptor for CCL19 and chemerin/RARRES2. Does not appear to be a signaling receptor, but may have a role in modulating chemokine-triggered immune responses by capturing and internalizing CCL19 or by presenting RARRES2 ligand to CMKLR1, a functional signaling receptors. Plays a critical role for the development of Th2 responses

More Common Targets

CCS | CCSAP | CCSER1 | CCSER2 | CCT2 | CCT3 | CCT4 | CCT5 | CCT6A | CCT6B | CCT6P1 | CCT6P3 | CCT7 | CCT8 | CCT8L1P | CCT8L2 | CCT8P1 | CCZ1 | CCZ1B | CCZ1P-OR7E38P | CD101 | CD101-AS1 | CD109 | CD14 | CD151 | CD160 | CD163 | CD163L1 | CD164 | CD164L2 | CD177 | CD177P1 | CD180 | CD19 | CD1A | CD1B | CD1C | CD1D | CD1E | CD2 | CD200 | CD200R1 | CD200R1L | CD207 | CD209 | CD22 | CD226 | CD24 | CD244 | CD247 | CD248 | CD24P2 | CD27 | CD27-AS1 | CD274 | CD276 | CD28 | CD2AP | CD2BP2 | CD3 Complex (T Cell Receptor Complex) | CD300A | CD300C | CD300E | CD300LB | CD300LD | CD300LD-AS1 | CD300LF | CD300LG | CD302 | CD320 | CD33 | CD34 | CD36 | CD37 | CD38 | CD3D | CD3E | CD3G | CD4 | CD40 | CD40LG | CD44 | CD44-DT | CD46 | CD47 | CD48 | CD5 | CD52 | CD53 | CD55 | CD58 | CD59 | CD5L | CD6 | CD63 | CD68 | CD69 | CD7 | CD70 | CD72