Target Name: CD247
NCBI ID: G919
Other Name(s): CD247 molecule | CD247 variant 2 | CD3-ZETA | tissue factor-targeting CAR1 dimer | CD247 molecule, transcript variant 1 | CD3H | CD247 antigen, zeta subunit | T3Z | CD247 molecule, transcript variant 4 | CD3Q | CD3Z | T-cell surface glycoprotein CD3 zeta chain (isoform 2) | T-cell surface glycoprotein CD3 zeta chain precursor | CD3Z antigen, zeta polypeptide (TiT3 complex) | TCR zeta chain | T-cell receptor T3 zeta chain | tissue factor-targeting CAR1 monomer | CD3Z_HUMAN | CD3ZETA | CD3zeta chain | T-cell antigen receptor complex, zeta subunit of CD3 | T-cell surface glycoprotein CD3 zeta chain (isoform 1) | CD247 variant 4 | T-cell surface glycoprotein CD3 zeta chain | CD247 molecule, transcript variant 2 | T-cell surface glycoprotein CD3 zeta chain (isoform 4) | CD247 variant 1 | TCRZ | IMD25 | CD3 zeta Polypeptide

CD247: A Promising Drug Target and Biomarker

CD247, also known as CD247 molecule, is a protein that is expressed in various tissues throughout the body. It is a member of the integrin complex, which is a group of transmembrane proteins that play a crucial role in cell-cell adhesion, migration, and invasion. CD247 has been identified as a potential drug target and biomarker due to its unique structure, expression patterns, and involvement in various biological processes.

Structure and Expression

CD247 is a 21-kDa protein that consists of a N-terminus, a transmembrane region, and an C-terminus. The N-terminus contains a cytoplasmic domain that is involved in protein-protein interactions, while the transmembrane region is responsible for the protein's ability to interact with the cell surface. The C-terminus is a cytoplasmic tail that is involved in the regulation of cellular processes, such as cell adhesion and migration.

CD247 is expressed in various tissues, including blood vessels, liver, spleen, and human fetal tissue. The expression level of CD247 varies depending on the tissue and developmental stage of the organism. For example, CD247 is highly expressed in the human placenta during the third trimester, and its expression level decreases with age.

CD247 is involved in various biological processes, including cell adhesion, migration, and invasion. It is a critical regulator of cell-cell adhesion, as it plays a role in the formation of tight junctions anddesmosomes, which are essential for the maintenance of tissue structure and function. CD247 is also involved in the regulation of cell migration, as it has been shown to promote the migration of various cell types, including cancer cells.

CD247 has also been shown to be involved in the regulation of inflammation and immune responses. For example, studies have shown that CD247 can modulate the expression of immune cell markers, including T cells and monocytes, and can also contribute to the regulation of inflammation.

Drug Target Potential

CD247 has been identified as a potential drug target due to its unique structure and the involvement in various biological processes. One of the main reasons for its potential as a drug target is its involvement in the regulation of cell-cell adhesion, which is a crucial aspect of many diseases, including cancer.

CD247 has been shown to play a role in the regulation of cell-cell adhesion by regulating the formation of tight junctions anddesmosomes, which are essential for the maintenance of tissue structure and function. Its involvement in this process makes it an attractive target for drugs that are designed to disrupt cell-cell adhesion, such as those that are used to treat cancer.

Another potential mechanism by which CD247 may be targeted by drugs is its involvement in the regulation of cell migration. Cancer cells are known to have the ability to migrate throughout the body and can give rise to tumors. CD247 has been shown to promote the migration of cancer cells, which makes it an attractive target for drugs that are designed to inhibit cell migration.

In addition to its potential role in cell-cell adhesion and migration, CD247 has also been shown to be involved in the regulation of inflammation and immune responses. This makes it an attractive target for drugs that are designed to modulate these processes and may contribute to the development of various diseases.

Biomarker Potential

CD247 has also been identified as a potential biomarker for several diseases, including cancer. Its expression level is often reduced in cancer cells compared to normal tissues, which makes it an attractive target for biomarkers that can be used to diagnose or monitor the progression of cancer.

CD247 has been shown to play a role in the regulation of cell

Protein Name: CD247 Molecule

Functions: Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response. When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR-mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD3Z. All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain. Upon TCR engagement, these motifs become phosphorylated by Src family protein tyrosine kinases LCK and FYN, resulting in the activation of downstream signaling pathways (PubMed:2470098, PubMed:7509083). CD3Z ITAMs phosphorylation creates multiple docking sites for the protein kinase ZAP70 leading to ZAP70 phosphorylation and its conversion into a catalytically active enzyme (PubMed:7509083). Plays an important role in intrathymic T-cell differentiation. Additionally, participates in the activity-dependent synapse formation of retinal ganglion cells (RGCs) in both the retina and dorsal lateral geniculate nucleus (dLGN) (By similarity)

More Common Targets

CD248 | CD24P2 | CD27 | CD27-AS1 | CD274 | CD276 | CD28 | CD2AP | CD2BP2 | CD3 Complex (T Cell Receptor Complex) | CD300A | CD300C | CD300E | CD300LB | CD300LD | CD300LD-AS1 | CD300LF | CD300LG | CD302 | CD320 | CD33 | CD34 | CD36 | CD37 | CD38 | CD3D | CD3E | CD3G | CD4 | CD40 | CD40LG | CD44 | CD44-DT | CD46 | CD47 | CD48 | CD5 | CD52 | CD53 | CD55 | CD58 | CD59 | CD5L | CD6 | CD63 | CD68 | CD69 | CD7 | CD70 | CD72 | CD74 | CD79A | CD79B | CD8 | CD80 | CD81 | CD81-AS1 | CD82 | CD83 | CD84 | CD86 | CD8A | CD8B | CD8B2 | CD9 | CD93 | CD96 | CD99 | CD99L2 | CD99P1 | CDA | CDADC1 | CDAN1 | CDC123 | CDC14A | CDC14B | CDC14C | CDC16 | CDC20 | CDC20-DT | CDC20B | CDC20P1 | CDC23 | CDC25A | CDC25B | CDC25C | CDC26 | CDC27 | CDC27P2 | CDC34 | CDC37 | CDC37L1 | CDC37P1 | CDC40 | CDC42 | CDC42BPA | CDC42BPB | CDC42BPG | CDC42EP1 | CDC42EP2