Target Name: CD83
NCBI ID: G9308
Other Name(s): CD83 molecule, transcript variant 1 | CD83 molecule | cell surface protein HB15 | hCD83 | CD83 antigen (activated B lymphocytes, immunoglobulin superfamily) | CD83_HUMAN | HB15 | BL11 | B-cell activation protein | CD83 antigen | CD83 antigen (isoform a) | CD83 variant 1 | cell-surface glycoprotein | Cell surface protein HB15

CD83: A Potential Drug Target and Biomarker

Introduction

CD83 is a protein that is expressed in various tissues and cell types in the human body. It is a member of the immunoglobulin superfamily and is involved in the immune response. CD83 has been identified as a potential drug target and biomarker due to its unique structure and expression pattern. In this article, we will discuss the CD83 molecule, its transcript variant 1, and its potential as a drug target and biomarker.

Structure and Expression

CD83 is a type I transmembrane protein that consists of a variable region, a constant region, and an exchange region. The variable region contains the major antigens of CD83, including the cell surface antigens CD83.1 and CD83.2. The constant region contains a unique N-terminal domain that is involved in cell adhesion and interaction with other proteins. The exchange region is responsible for the exchange of CD83 between different cell types or tissues.

CD83 is expressed in various tissues and cell types, including blood cells, tissues, and organs. It is mainly expressed in the liver, where it is involved in the immune response. The expression pattern of CD83 is regulated by various factors, including growth factors , chemokines, and viral infections, etc.

CD83 has four known transcript variants, each with a different translation start site. CD83.1 is the most abundant variant and is mainly expressed in the liver. It is involved in the immune response, including the regulation of inflammation and immune tolerance. CD83. 2 is the second most abundant variant and is mainly expressed in the spleen. It is involved in the immune response and in the regulation of inflammation. CD83.3 and CD83.4 are less abundant variants that are mainly expressed in the skin and thymus, respectively.

CD83 has been shown to play a key role in the immune response by regulating the activation and proliferation of natural killer cells (NK cells), which are a crucial part of the immune system. NK cells are involved in the regulation of infection and inflammation, and their dysfunction has been associated with various diseases, including cancer, cardiovascular diseases, and neurodegenerative diseases.

CD83 has also been shown to play a role in cancer progression by promoting the survival and proliferation of cancer cells. The expression of CD83 has been observed in various types of cancer, including breast, lung, and colorectal cancer.

Potential Drug Target

CD83 has been identified as a potential drug target due to its unique structure and expression pattern. The N-terminal domain of CD83 contains a unique transmembrane domain that is involved in cell adhesion and interaction with other proteins. This domain is also involved in the regulation of various signaling pathways, including the T cell signaling pathway.

CD83 has been shown to play a role in the regulation of T cell proliferation and differentiation. CD83 has been shown to interact with the transcription factor PDGF-1, which is involved in the regulation of T cell proliferation. Additionally, CD83 has been shown to interact with the protein NF-kappa-B, which is involved in the regulation of inflammation and immune responses.

CD83 has also been shown to play a role in the regulation of natural killer cell (NK) proliferation and differentiation. CD83 has also been shown to interact with the protein PDGF-2, which is involved in the regulation of NK cell proliferation.

Biomarker

CD83 has been identified as a potential biomarker for various diseases, including cancer, cardiovascular diseases, and neurodegenerative diseases. The expression of CD83 has been shown to be affected by various factors, including growth factors, chemokines, and viruses.

In addition, the expression of CD83 has

Protein Name: CD83 Molecule

Functions: May play a significant role in antigen presentation or the cellular interactions that follow lymphocyte activation

More Common Targets

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