Target Name: CD80
NCBI ID: G941
Other Name(s): B7.1 | CD80 antigen (CD28 antigen ligand 1, B7-1 antigen) | costimulatory factor CD80 | T-lymphocyte activation antigen CD80 | Activation B7-1 antigen | activation B7-1 antigen | Costimulatory factor CD80 | Costimulatory molecule variant IgV-CD80 | B7 | costimulatory molecule variant IgV-CD80 | OTTHUMP00000215214 | CD80_HUMAN | B7-1 (CD80 antigen) | CD28LG1 | B7-1 | LAB7 | B-lymphocyte activation antigen B7 | CD80 molecule | CD28 antigen ligand 1, B7-1 antigen | OTTHUMP00000215215 | CD28LG | BB1 | CTLA-4 counter-receptor B7.1

CD80 as a Drug Target and Biomarker: Implications for Cancer Treatment

CD80 is a protein that is expressed in various tissues of the body, including the immune system, skin, and nervous system. It is a member of the B7 superfamily and is known for its role in the regulation of cell proliferation, differentiation, and survival. CD80 has also been implicated in cancer progression and treatment response. As a drug target and biomarker, CD80 has potential for the development of new treatments for various types of cancer.

CD80 as a Drug Target

CD80 has been identified as a potential drug target due to its involvement in several cellular processes that are associated with cancer progression. One of the key functions of CD80 is its role in the regulation of T cell development and function. CD80 has been shown to promote the development and activation of CD8+ T cells, which are known for their ability to recognize and destroy cancer cells.

In addition to its role in T cell development, CD80 has also been shown to play a role in the regulation of immune cell function. CD80 has been shown to regulate the production of regulatory T cells, which are responsible for maintaining and regulating CD4+ T cell function. This regulation of T cell function is critical for the development of immune-mediated cancer vaccines and adoptive T cell therapy.

CD80 as a Biomarker

CD80 has also been used as a biomarker for cancer diagnosis and treatment. By measuring the expression of CD80 in cancer cells, researchers can determine the level of interest in a particular treatment. This is because cancer cells that have high levels of CD80 are more likely to respond to a particular treatment.

One of the key advantages of using CD80 as a biomarker is its stability. Unlike some other biomarkers, such as cancer cell volume, CD80 has been shown to remain stable even in the presence of various treatments. This stability makes it a more reliable indicator of treatment response than some other biomarkers.

CD80 has also been used as a biomarker for the evaluation of cancer-associated pain. By measuring the expression of CD80 in cancer-associated pain, researchers can determine the level of pain associated with a particular treatment. This information can be used to determine the most effective treatments for managing cancer-associated pain.

Conclusion

CD80 has shown to be a protein that plays a critical role in the regulation of cell proliferation and differentiation, as well as the development and function of the immune system. As a drug target and biomarker, CD80 has the potential for the development of new treatments for various types of cancer. Further research is needed to fully understand the role of CD80 in cancer biology and its potential as a drug target.

Protein Name: CD80 Molecule

Functions: Involved in the costimulatory signal essential for T-lymphocyte activation. T-cell proliferation and cytokine production is induced by the binding of CD28, binding to CTLA-4 has opposite effects and inhibits T-cell activation

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