Target Name: CD44
NCBI ID: G960
Other Name(s): PGP-I | H-CAM | MDU3 | CD44 intracellular domain | soluble CD44 | Epican | CD44R | Heparan sulfate proteoglycan | HCELL | CD44 molecule (Indian blood group), transcript variant 3 | CDW44 | CD44 antigen (isoform 5) | MC56 | extracellular matrix receptor III | homing cell adhesion molecule | Chondroitin sulfate proteoglycan 8 | CD44 antigen (isoform 3) | hematopoietic cell E- and L-selectin ligand | Hermes-1 | CD44 isoform RC | CD44 antigen (isoform 1) | CD44 (ICD) | Indian blood group antigen | CD44 soluble ectodomain | GP90 lymphocyte homing/adhesion receptor | CD44 (EXT) | ECMR-III | CD44 molecule (Indian blood group), transcript variant 5 | sCD44 | CD44 extracellular truncation | CD44 variant 5 | CD44 variant 3 | CD44 variant 4 | CD44R2 | Hyaluronate receptor | IN | CD44 (ICD)_(HUMAN) | Homing function and Indian blood group system | CD44 soluble | phagocyte glycoprotein 1 | CDw44 | Phagocytic glycoprotein 1 | Phagocytic glycoprotein I | epican | homing function and Indian blood group system | CD44 variant 6 | CD44 antigen (isoform 6) | CD44 molecule (Indian blood group), transcript variant 6 | HUTCH-1 | CD44 molecule (Indian blood group) | hyaluronate receptor | CD44 molecule (Indian blood group), transcript variant 1 | CD44 molecule (Indian blood group), transcript variant 4 | ECM-III | Hematopoietic cell E- and L-selectin ligand | MDU2 | phagocytic glycoprotein 1 | CD44 antigen | CD44 soluble_(HUMAN) | LHR | In(Lu) related-p80 | CD44_HUMAN | CD44 variant 1 | CD44 (EXT)_(HUMAN) | CSPG8 | Cell surface glycoprotein CD44 | cell surface glycoprotein CD44 | Extracellular matrix receptor III | HUTCH-I | MIC4 | chondroitin sulfate proteoglycan 8 | heparan sulfate proteoglycan | Pgp1 | Hermes antigen | CD44 antigen (isoform 4) | PGP-1

CD44: A Protein as A Potential Drug Target

CD44 (Perlecan) is a protein that is expressed in various tissues throughout the body, including the skin, hair, nails, and connective tissue. It is a member of the mucin family and has been identified as a potential drug target.

CD44 is involved in many different processes in the body, including cell adhesion, migration, and invasion. It is a co-factor for the protein PDGFR-尾, which is involved in the development and progression of many types of cancer, including breast cancer.

CD44 has also been shown to be involved in the development and progression of neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease. It is thought to play a role in the recruitment of neurons to the blood-brain barrier and the regulation of neurotransmitter release, which may contribute to the development of these conditions.

In addition to its role in cancer and neurodegenerative diseases, CD44 is also thought to be involved in the regulation of inflammation and immune responses. It is a co-factor for the protein NF-kappa-B, which is involved in the regulation of inflammation and immune responses. responses.

CD44 has also been shown to be involved in the regulation of cell growth and the maintenance of stem cell properties. It is a co-factor for the protein PDGFR-伪, which is involved in the regulation of cell growth and the association with stem cell properties.

In conclusion, CD44 is a protein that is involved in a wide range of processes in the body, including cell adhesion, migration, and invasion, and has been identified as a potential drug target. Its role in the development and progression of cancer, neurodegenerative diseases, and inflammation may make it an attractive target for future research and development.

(1) CD44 as a drug target: A review.
(2) CD44 as a therapeutic target for neurodegenerative diseases.
(3) CD44 as a potential therapeutic target for cancer.
(4) CD44 as a regulator of inflammation and immune responses.
(5) CD44 as a regulator of cell growth and stem cell properties.

Protein Name: CD44 Molecule (Indian Blood Group)

Functions: Cell-surface receptor that plays a role in cell-cell interactions, cell adhesion and migration, helping them to sense and respond to changes in the tissue microenvironment (PubMed:16541107, PubMed:19703720, PubMed:22726066). Participates thereby in a wide variety of cellular functions including the activation, recirculation and homing of T-lymphocytes, hematopoiesis, inflammation and response to bacterial infection (PubMed:7528188). Engages, through its ectodomain, extracellular matrix components such as hyaluronan/HA, collagen, growth factors, cytokines or proteases and serves as a platform for signal transduction by assembling, via its cytoplasmic domain, protein complexes containing receptor kinases and membrane proteases (PubMed:18757307, PubMed:23589287). Such effectors include PKN2, the RhoGTPases RAC1 and RHOA, Rho-kinases and phospholipase C that coordinate signaling pathways promoting calcium mobilization and actin-mediated cytoskeleton reorganization essential for cell migration and adhesion (PubMed:15123640)

More Common Targets

CD44-DT | CD46 | CD47 | CD48 | CD5 | CD52 | CD53 | CD55 | CD58 | CD59 | CD5L | CD6 | CD63 | CD68 | CD69 | CD7 | CD70 | CD72 | CD74 | CD79A | CD79B | CD8 | CD80 | CD81 | CD81-AS1 | CD82 | CD83 | CD84 | CD86 | CD8A | CD8B | CD8B2 | CD9 | CD93 | CD96 | CD99 | CD99L2 | CD99P1 | CDA | CDADC1 | CDAN1 | CDC123 | CDC14A | CDC14B | CDC14C | CDC16 | CDC20 | CDC20-DT | CDC20B | CDC20P1 | CDC23 | CDC25A | CDC25B | CDC25C | CDC26 | CDC27 | CDC27P2 | CDC34 | CDC37 | CDC37L1 | CDC37P1 | CDC40 | CDC42 | CDC42BPA | CDC42BPB | CDC42BPG | CDC42EP1 | CDC42EP2 | CDC42EP3 | CDC42EP4 | CDC42EP5 | CDC42SE1 | CDC42SE2 | CDC45 | CDC5L | CDC5L complex | CDC6 | CDC7 | CDC73 | CDCA2 | CDCA3 | CDCA4 | CDCA4P3 | CDCA5 | CDCA7 | CDCA7L | CDCA8 | CDCP1 | CDCP2 | CDH1 | CDH10 | CDH11 | CDH12 | CDH13 | CDH13-AS2 | CDH15 | CDH16 | CDH17 | CDH18 | CDH19