Cohesin Complex: A novel Drug Target and Biomarker (P16384)

Target Name: Cohesin complex

NCBI ID: P16384

Other Name(s): None

Cohesin Complex: A novel Drug Target and Biomarker

Cohesin complex is a protein that plays a crucial role in the regulation of DNA replication during cell division. It is a complex of several proteins that work together to ensure the proper order of DNA double-strands during the replication process. The cohesin complex is essential for the formation of a stable double- helix, which ensures the accuracy of DNA replication and the formation of an effective genetic template for cell growth and division.

Recent studies have identified cohesin complex as a potential drug target and biomarker. The cohesin complex is a protein that can be targeted by small molecules, making it an attractive target for drug development. Additionally, the cohesin complex is also a well-established biomarker for several diseases, including cancer, and its dysfunction has been implicated in several diseases, making it an important biomarker for diagnostic purposes.

Drug Targets

The cohesin complex is a protein that can be targeted by small molecules due to its unique structure and its subcellular localization. The cohesin complex is primarily localized to the nucleus and is composed of several proteins that work together to form a complex structure.

One of the key drug targets for the cohesin complex is the inhibition of the cohesin complex activity. The inhibition of cohesin complex activity can lead to the disruption of the double-helix, which can result in DNA replication errors and an increased risk of genetic mutations.

An inhibitor of the cohesin complex, such as the drug nocodazole, has been shown to inhibit the activity of the cohesin complex and prevent the formation of double-helixes during DNA replication. Additionally, studies have shown that inhibitors of the cohesin complex have potential therapeutic benefits in cancer treatment.

Biomarkers

Cohesin complex is also a well-established biomarker for several diseases, including cancer. The dysfunction of the cohesin complex has been implicated in the development and progression of several diseases, including cancer.

One of the key biomarkers for cancer is the expression of the cohesin complex proteins. Several studies have shown that the expression of cohesin complex proteins is significantly increased in cancer tissues compared to normal tissues. Additionally, the dysfunction of the cohesin complex has been implicated in the development and progression of several types of cancer, including breast cancer, lung cancer, and colorectal cancer.

Another biomarker for cancer is the formation of double-helix breaks during DNA replication. Studies have shown that the dysfunction of the cohesin complex can lead to the formation of double-helix breaks during DNA replication, which can increase the risk of genetic mutations.

Conclusion

In conclusion, cohesin complex is a protein that plays a crucial role in the regulation of DNA replication during cell division. Its dysfunction has been implicated in several diseases, including cancer. The cohesin complex is also a potential drug target and biomarker, and its inhibition has potential therapeutic benefits in cancer treatment. Further research is needed to fully understand the role of the cohesin complex and its potential as a drug target and biomarker.

Protein Name: Cohesin Complex

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