Calcium Release-Activated Channel (CRAC): A Drug Target and Potential Biomarker

Target Name: Calcium release-activated channel (CRAC)

NCBI ID: P6463

Other Name(s): Ca(2+) release-activated Ca(2+) (CRAC) channel | CRAC calcium channel | CRAC

Calcium Release-Activated Channel (CRAC): A Drug Target and Potential Biomarker

Abstract:

Calcium release-activated channel (CRAC) is a critical channel that plays a significant role in neurotransmission and signaling. The CRAC channel is a non-selective cation channel that allows the entry of calcium ions (Ca2+) in response to changes in membrane potential. It is a transmembrane protein that consists of an extracellular domain, a transmembrane domain, and an intracellular domain. The CRAC channel is involved in various physiological processes, including neurotransmission, pain perception, and muscle contractions. In addition, the CRAC channel has also been identified as a potential drug target and biomarker. This article aims to provide an overview of the CRAC channel, its function, and potential as a drug target.

Introduction:

The calcium ions (Ca2+) play a crucial role in various physiological processes, including neurotransmission, muscle contractions, and intracellular signaling. They are involved in the regulation of many cellular processes, including cell division, cell signaling, and neurotransmission. The CRAC channel is a critical channel that allows the entry of calcium ions in response to changes in membrane potential. It is a transmembrane protein that consists of an extracellular domain, a transmembrane domain, and an intracellular domain.

The CRAC channel is involved in various physiological processes, including:

* neurotransmission: The CRAC channel is involved in the regulation of neurotransmitter release and the maintenance of the resting membrane potential. It is also involved in the regulation of neurotransmitter uptake and release.
* pain perception: The CRAC channel is involved in the regulation of pain perception. It is activated by pain-related stimuli and plays a role in the transmission of pain signals from the nervous system to the brain.
* muscle contractions: The CRAC channel is involved in the regulation of muscle contractions. It is activated by muscle-related stimuli and plays a role in the transmission of muscle signals from the nervous system to the muscle fibers.

In addition, the CRAC channel has also been identified as a potential drug target and biomarker. The CRAC channel has been shown to be involved in various diseases, including epilepsy, migraine, and neurodegenerative diseases. In addition, the CRAC channel has also been shown to be a potential biomarker for certain diseases, such as cancer and neuroinflammation.

The CRAC channel is a non-selective cation channel that allows the entry of calcium ions in response to changes in membrane potential. It is a transmembrane protein that consists of an extracellular domain, a transmembrane domain, and an intracellular domain. The CRAC channel is expressed in various tissues and cells and plays a role in various physiological processes.

The CRAC channel is involved in the regulation of neurotransmission, pain perception, and muscle contractions. It is a critical channel that allows the entry of calcium ions in response to changes in membrane potential. The CRAC channel has also been identified as a potential drug target and biomarker.

Conclusion:

The CRAC channel is a non-selective cation channel that is involved in the regulation of neurotransmission, pain perception, and muscle contractions. It is a transmembrane protein that consists of an extracellular domain, a transmembrane domain, and an intracellular domain. The CRAC channel is a critical channel that allows the entry of calcium ions in response to changes in membrane potential. It is also involved in various physiological processes, including the regulation of neurotransmission, pain perception, and muscle contractions. The CRAC channel has

Protein Name: Calcium Release-activated Channel (CRAC)

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