JMJD7: A Promising Drug Target / Biomarker (G100137047)

Target Name: JMJD7

NCBI ID: G100137047

JMJD7: A Promising Drug Target / Biomarker

JMJD7, also known as heat shock protein-42 (Hsp42), is a protein that plays a crucial role in the regulation of cellular stress responses. JMJD7 is a heat shock protein (HSP) that is expressed in a variety of cell types, including muscle, nerve, heart, and brain cells. It is known for its ability to localize to the endoplasmic reticulum (ER) and to interact with various cellular signaling pathways, including the TGF-β pathway.

JMJD7 functions as a negative regulator of the TGF-β pathway

The TGF-β pathway is a well-established signaling pathway that is involved in a wide range of cellular processes, including cell growth, differentiation, and stress responses. This pathway is activated in response to various stressors, including temperature, stress, and growth factors. The TGF-β pathway is activated by the binding of the transcription factor, transforminger factor beta (T尾), to its receptor, which is located in the cytoplasm.

JMJD7 functions as a negative regulator of the TGF-β pathway by binding to the T尾 receptor and preventing it from activating the pathway. JMJD7 is able to interact with T尾 in a region known as the N-terminus. This interaction between JMJD7 and T尾 allows T尾 to inhibit the activity of various downstream signaling proteins, including the Smad transcription factor, which is involved in the regulation of cell growth and differentiation.

JMJD7 is also involved in the regulation of cellular stress responses

Stress responses are critical for the survival and proper functioning of cells. JMJD7 is involved in the regulation of cellular stress responses by participating in various stress-responsive pathways. For example, JMJD7 has been shown to be involved in the regulation of the unfolded-protein response (UPR), a stress-responsive pathway that is involved in the regulation of protein stability and localization.

JMJD7 is also involved in the regulation of protein homeostasis

Protein homeostasis is the process by which cells maintain the stability of their protein concentrations within a narrow range. JMJD7 is involved in the regulation of protein homeostasis by participating in various signaling pathways that are involved in the regulation of protein synthesis, degradation, and localization.

JMJD7 is a potential drug target

JMJD7 is a protein that has been identified as a potential drug target due to its involvement in various cellular signaling pathways. JMJD7 has been shown to be involved in a wide range of cellular processes, including the regulation of cell growth, differentiation, and stress responses.

In addition, JMJD7 has also been shown to play a role in the regulation of protein stability and localization, as well as the regulation of protein homeostasis. These properties make JMJD7 an attractive target for drug development, particularly for the treatment of diseases that are characterized by the disruption of cellular homeostasis, such as cancer, neurodegenerative diseases, and autoimmune diseases.

Conclusion

JMJD7 is a heat shock protein that is involved in a wide range of cellular processes, including the regulation of cell growth, differentiation, and stress responses. It is also involved in the regulation of protein stability and localization, as well as the regulation of protein homeostasis. These properties make JMJD7 an attractive target for drug development, particularly for the treatment of diseases that are characterized by the disruption of cellular homeostasis. Further research is needed to fully understand the role of JMJD7 in cellular processes and to develop effective treatments for diseases that are characterized by the disruption of

Protein Name: Jumonji Domain Containing 7

Functions: Bifunctional enzyme that acts both as an endopeptidase and 2-oxoglutarate-dependent monooxygenase (PubMed:28847961, PubMed:29915238). Endopeptidase that cleaves histones N-terminal tails at the carboxyl side of methylated arginine or lysine residues, to generate 'tailless nucleosomes', which may trigger transcription elongation (PubMed:28847961). Preferentially recognizes and cleaves monomethylated and dimethylated arginine residues of histones H2, H3 and H4 (PubMed:28847961). After initial cleavage, continues to digest histones tails via its aminopeptidase activity (PubMed:28847961). Additionally, may play a role in protein biosynthesis by modifying the translation machinery (PubMed:29915238). Acts as Fe(2+) and 2-oxoglutarate-dependent monooxygenase, catalyzing (S)-stereospecific hydroxylation at C-3 of 'Lys-22' of DRG1 and 'Lys-21' of DRG2 translation factors (TRAFAC), promoting their interaction with ribonucleic acids (RNA) (PubMed:29915238)

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