Target Name: LMAN2
NCBI ID: G10960
Other Name(s): glycoprotein GP36b | LMAN2_HUMAN | Vesicular integral protein of 36 kDa | vesicular integral-membrane protein 36 | GP36B | Lectin, mannose binding 2 | Lectin mannose-binding 2 | vesicular integral protein of 36 kDa | Glycoprotein GP36b | lectin, mannose binding 2 | VIP36 | Vesicular integral-membrane protein 36 | Vesicular integral-membrane protein VIP36 | epididymis secretory sperm binding protein | C5orf8

Understanding GP36b: Unraveling Its Role in Physiological Processes

Glycoprotein GP36b, also known as LMAN2, is a protein that is expressed in various tissues throughout the body. It is a member of the glycoprotein family, which is a type of protein that is composed of a glycine tail and one or more cysteines amino acid residues. GP36b is a glycoprotein that is expressed in the liver, heart, kidneys, and pancreas, among other tissues. It is involved in various physiological processes in the body, including blood clotting, inflammation, and signaling. As a result, GP36b has been identified as a potential drug target or biomarker.

One of the key functions of GP36b is its role in blood clotting. Clotting is a critical physiological process that helps to prevent blood from bleeding excessively. GP36b is involved in the formation of platelet aggregates, which are the building blocks of blood clots. When a person is injured and their blood vessel is broken, platelets are released from the bloodstream to help to heal the wound. GP36b plays a key role in this process by helping to regulate the release of platelets from the bloodstream.

In addition to its role in blood clotting, GP36b is also involved in signaling. It is a potent negative regulator of the Shc/FAK signaling pathway, which is a critical pathway that is involved in many cellular processes, including cell growth, differentiation, and survival. GP36b helps to regulate the activity of the Shc protein, which is a negative regulator of the FAK pathway. This means that when the Shc protein is activated, GP36b helps to prevent the FAK pathway from being activated.

GP36b is also involved in inflammation. It is a potent regulator of the NF-kappa-B signaling pathway, which is a critical pathway that is involved in inflammation. NF-kappa-B is a protein that is involved in the regulation of inflammation, and GP36b helps to regulate its activity. This means that when the NF-kappa-B pathway is activated, GP36b helps to prevent inflammation from occurring.

GP36b is also involved in many other physiological processes in the body. It is a regulator of cell adhesion, which is the process by which cells stick together to form tissues. It is also involved in the regulation of cell signaling, as well as the regulation of cellular uptake of nutrients.

Despite its involvement in many important physiological processes, GP36b is not well understood. There are currently few research studies that have focused on its role in these processes. As a result, there is a need for further research to be conducted in order to fully understand the role of GP36b in the body.

In conclusion, GP36b is a protein that is involved in various physiological processes in the body. It is a member of the glycoprotein family and plays a key role in blood clotting, signaling, and inflammation. As a result, GP36b has been identified as a potential drug target or biomarker. Further research is needed to fully understand its role in the body and to develop new treatments.

Protein Name: Lectin, Mannose Binding 2

Functions: Plays a role as an intracellular lectin in the early secretory pathway. Interacts with N-acetyl-D-galactosamine and high-mannose type glycans and may also bind to O-linked glycans. Involved in the transport and sorting of glycoproteins carrying high mannose-type glycans (By similarity)

More Common Targets

LMAN2L | LMBR1 | LMBR1L | LMBRD1 | LMBRD2 | LMCD1 | LMCD1-AS1 | LMF1 | LMF2 | LMLN | LMNA | LMNB1 | LMNB2 | LMNTD1 | LMNTD2 | LMNTD2-AS1 | LMO1 | LMO2 | LMO3 | LMO4 | LMO7 | LMO7-AS1 | LMO7DN | LMOD1 | LMOD2 | LMOD3 | LMTK2 | LMTK3 | LMX1A | LMX1B | LMX1B-DT | LNC-LBCS | LNCAROD | LNCARSR | LNCATV | LNCNEF | LNCOC1 | LNCOG | LNCPRESS1 | LNCRI | LNCRNA-ATB | LNCRNA-IUR | LNCTAM34A | LNP1 | LNPEP | LNPK | LNX1 | LNX1-AS1 | LNX2 | LOC100127946 | LOC100127955 | LOC100128002 | LOC100128028 | LOC100128050 | LOC100128059 | LOC100128079 | LOC100128093 | LOC100128164 | LOC100128242 | LOC100128288 | LOC100128317 | LOC100128361 | LOC100128398 | LOC100128494 | LOC100128593 | LOC100128770 | LOC100128966 | LOC100128988 | LOC100129034 | LOC100129098 | LOC100129148 | LOC100129175 | LOC100129203 | LOC100129215 | LOC100129316 | LOC100129381 | LOC100129434 | LOC100129455 | LOC100129534 | LOC100129603 | LOC100129697 | LOC100130000 | LOC100130207 | LOC100130285 | LOC100130298 | LOC100130331 | LOC100130452 | LOC100130463 | LOC100130548 | LOC100130587 | LOC100130691 | LOC100130698 | LOC100130744 | LOC100130748 | LOC100130872 | LOC100130899 | LOC100130938 | LOC100130987 | LOC100130992 | LOC100131096