Target Name: USP18
NCBI ID: G11274
Other Name(s): ISG15-specific-processing protease | Ubiquitin specific protease 18 | PTORCH2 | ISG43 | UBP18_HUMAN | UBP43 | Ubl thioesterase 18 | Ubiquitin specific peptidase 18 | ubl thioesterase 18 | ubl thiolesterase 18 | hUBP43 | 43 kDa ISG15-specific protease | ubiquitin specific protease 18 | ubiquitin specific peptidase 18 | Ubl carboxyl-terminal hydrolase 18

Unlocking The Potential of USP18: A Unexplored Drug Target

USP18 (ISG15-specific-processing protease) is a protein that is expressed in various tissues of the body, including the liver, pancreas, and spleen. It is a part of the immune system and is involved in the regulation of inflammation and tissue repair.

Research has shown that USP18 plays a crucial role in the immune response and has been implicated in a number of diseases, including cancer, autoimmune disorders, and obesity. Its functions include the regulation of immune cell function, the production of pro-inflammatory cytokines, and the modulation of cellular signaling pathways that promote inflammation and tissue damage.

One of the key functions of USP18 is its role in the regulation of inflammation. It has been shown to play a key role in the production and regulation of pro-inflammatory cytokines, such as TNF-伪, IL-1尾, and IL-6. These cytokines are involved in the recruitment of immune cells to the site of inflammation, the regulation of inflammation-induced tissue damage, and the regulation of immune cell function.

In addition to its role in inflammation, USP18 has also been shown to be involved in the regulation of tissue repair. It has been shown to play a key role in the regulation of cell proliferation and the production of new tissues during wound healing.

Despite its potential therapeutic applications, USP18 is still an unexplored drug target. Further research is needed to fully understand its functions and to determine the best way to target it in order to treat disease.

In conclusion, USP18 (ISG15-specific-processing protease) is a protein that is involved in the regulation of inflammation and tissue repair. Further research is needed to fully understand its functions and to determine the best way to target it in order to treat disease.

Protein Name: Ubiquitin Specific Peptidase 18

Functions: Interferon-induced ISG15-specific protease that plays a crucial role for maintaining a proper balance of ISG15-conjugated proteins in cells (PubMed:11788588). Regulates protein ISGylation by efficiently cleaving ISG15 conjugates linked via isopeptide bonds. Regulates T-cell activation and T-helper 17 (Th17) cell differentiation by deubiquitinating TAK1, likely to keep TAK1-TAB complexes in steady conditions (PubMed:23825189). In turn, restricts activation of NF-kappa-B, NFAT, and JNK as well as expression of IL2 in T-cells after TCR activation (PubMed:23825189). Acts as a molecular adapter with USP20 to promote innate antiviral response through deubiquitinating STING1 (PubMed:27801882). Involved also in the negative regulation of the inflammatory response triggered by type I interferon (PubMed:28165510, PubMed:27325888). Upon recruitment by STAT2 to the type I interferon receptor subunit IFNAR2 interferes with the assembly of the ternary interferon-IFNAR1-IFNAR2 complex and acts as a negative regulator of the type I interferon signaling pathway (PubMed:28165510)

More Common Targets

USP19 | USP2 | USP2-AS1 | USP20 | USP21 | USP22 | USP24 | USP25 | USP26 | USP27X | USP27X-DT | USP28 | USP29 | USP3 | USP3-AS1 | USP30 | USP30-AS1 | USP31 | USP32 | USP32P1 | USP32P2 | USP32P3 | USP33 | USP34 | USP35 | USP36 | USP37 | USP38 | USP39 | USP4 | USP40 | USP41 | USP42 | USP43 | USP44 | USP45 | USP46 | USP46-DT | USP47 | USP48 | USP49 | USP5 | USP50 | USP51 | USP53 | USP54 | USP6 | USP6NL | USP6NL intronic transcript 1 (non-protein coding), transcript variant 1 | USP7 | USP8 | USP8P1 | USP9X | USP9Y | USPL1 | UST | UTF1 | UTP11 | UTP14A | UTP14C | UTP15 | UTP18 | UTP20 | UTP23 | UTP25 | UTP3 | UTP4 | UTP6 | UTRN | UTS2 | UTS2B | UTS2R | UTY | UVRAG | UVSSA | UXS1 | UXT | UXT-AS1 | VAC14 | Vacuolar H+ ATPase | VAMP1 | VAMP2 | VAMP3 | VAMP4 | VAMP5 | VAMP7 | VAMP8 | VANGL1 | VANGL2 | VAPA | VAPB | VARS1 | VARS2 | Vascular endothelial growth factor receptor (VEGFR) | Vascular endothelial growth factors (VEGF) | VASH1 | VASH1-AS1 | VASH2 | VASN | Vasoactive intestinal polypeptide receptor (VIP-R)