Target Name: USP30
NCBI ID: G84749
Other Name(s): ubiquitin-specific protease 30 | Ubiquitin carboxyl-terminal hydrolase 30 (isoform 1) | ubiquitin thiolesterase 30 | MGC10702 | Ubiquitin specific peptidase 30, transcript variant 1 | Ub-specific protease 30 | UBP30_HUMAN | ub-specific protease 30 | ubiquitin thioesterase 30 | ubiquitin specific peptidase 30 | Ubiquitin-specific protease 30 | Ubiquitin-specific-processing protease 30 | Ubiquitin specific peptidase 30, transcript variant 2 | deubiquitinating enzyme 30 | USP30 variant 1 | Ubiquitin thiolesterase 30 | Deubiquitinating enzyme 30 | Ubiquitin carboxyl-terminal hydrolase 30 | Ubiquitin specific protease 30 | Ubiquitin carboxyl-terminal hydrolase 30 (isoform 2) | USP30 variant 2 | Ubiquitin thioesterase 30 | FLJ40511 | ubiquitin-specific-processing protease 30

USP30: A Potential Drug Target and Biomarker

USP30, or Ubiquitin-Specific Protease 30, is a protein that plays a critical role in the ubiquitin system, which is a protein degradation pathway that helps remove damaged or unnecessary proteins from cells. Mutations in the USP30 gene have been linked to a range of diseases, including cancer, neurodegenerative diseases, and autoimmune disorders. As a result, USP30 has emerged as a promising drug target and biomarker for a variety of diseases.

The ubiquitin system is a complex series of proteins that work together to remove damaged or unnecessary proteins from cells. The system is composed of several different proteins, including USP30, which is a protein that plays a key role in the first step of the ubiquitin degradation pathway. USP30 helps to break down a type of protein called ubiquitin, which is a large protein that is involved in many different cellular processes.

When a protein is synthesized, it is typically capped with a Ubiquitin tag, which is a special kind of protein that helps to mark it for degradation. Once the Ubiquitin tag is attached to the protein, it is carried to the end of the protein and is degraded by the ubiquitin degradation pathway. USP30 is involved in breaking down the Ubiquitin tag and removing the Ubiquitin protein from the protein.

USP30 is a protein that is expressed in many different tissues and cells in the body. It is also highly conserved, which means that it is similar to other proteins that are found in the same family. This conservation allows scientists to study the role of USP30 in different biological processes and to use it as a drug target or biomarker.

One of the key features of USP30 is its ability to interact with other proteins. It has been shown to interact with a variety of proteins, including the protein USP25, which is also involved in the ubiquitin degradation pathway. The interaction between USP30 and USP25 allows for the formation of a complex that is involved in the degradation of certain proteins.

This interaction between USP30 and USP25 is important because it allows USP30 to influence the activity of USP25. For example, studies have shown that when USP30 is present, USP25 is more likely to be active, which could potentially lead to the degradation of certain proteins. This suggests that USP30 could be a useful drug target or biomarker for diseases associated with the activity of USP25.

Another potential way to study USP30 is to use it as a target for small molecules. Many drugs that are used to treat a variety of diseases work by binding to USP30 and inhibiting its activity. By using a variety of small molecules to test for drugs that interact with USP30, scientists can identify potential new treatments for a variety of diseases.

In addition to its potential as a drug target or biomarker, USP30 is also a potential biomarker for a variety of diseases. Because it is involved in the ubiquitin degradation pathway, USP30 levels are often reduced in diseases where the body is producing too much or too little of it. This can make it a useful marker for a variety of diseases, including cancer, neurodegenerative diseases, and autoimmune disorders.

Overall, USP30 is a protein that has the potential to be a drug target or biomarker for a variety of diseases. Its ability to interact with other proteins and to be influenced by small molecules makes it an attractive target for research into the role of ubiquitin in different biological processes

Protein Name: Ubiquitin Specific Peptidase 30

Functions: Deubiquitinating enzyme tethered to the mitochondrial outer membrane that acts as a key inhibitor of mitophagy by counteracting the action of parkin (PRKN): hydrolyzes ubiquitin attached by parkin on target proteins, such as RHOT1/MIRO1 and TOMM20, thereby blocking parkin's ability to drive mitophagy (PubMed:18287522, PubMed:24896179, PubMed:25527291, PubMed:25621951). Preferentially cleaves 'Lys-6'- and 'Lys-11'-linked polyubiquitin chains, 2 types of linkage that participate in mitophagic signaling (PubMed:25621951). Does not cleave efficiently polyubiquitin phosphorylated at 'Ser-65' (PubMed:25527291). Acts as negative regulator of mitochondrial fusion by mediating deubiquitination of MFN1 and MFN2 (By similarity)

More Common Targets

USP30-AS1 | USP31 | USP32 | USP32P1 | USP32P2 | USP32P3 | USP33 | USP34 | USP35 | USP36 | USP37 | USP38 | USP39 | USP4 | USP40 | USP41 | USP42 | USP43 | USP44 | USP45 | USP46 | USP46-DT | USP47 | USP48 | USP49 | USP5 | USP50 | USP51 | USP53 | USP54 | USP6 | USP6NL | USP6NL intronic transcript 1 (non-protein coding), transcript variant 1 | USP7 | USP8 | USP8P1 | USP9X | USP9Y | USPL1 | UST | UTF1 | UTP11 | UTP14A | UTP14C | UTP15 | UTP18 | UTP20 | UTP23 | UTP25 | UTP3 | UTP4 | UTP6 | UTRN | UTS2 | UTS2B | UTS2R | UTY | UVRAG | UVSSA | UXS1 | UXT | UXT-AS1 | VAC14 | Vacuolar H+ ATPase | VAMP1 | VAMP2 | VAMP3 | VAMP4 | VAMP5 | VAMP7 | VAMP8 | VANGL1 | VANGL2 | VAPA | VAPB | VARS1 | VARS2 | Vascular endothelial growth factor receptor (VEGFR) | Vascular endothelial growth factors (VEGF) | VASH1 | VASH1-AS1 | VASH2 | VASN | Vasoactive intestinal polypeptide receptor (VIP-R) | Vasohibin | Vasopressin Receptor | Vasopressin V1 Receptor | VASP | VAT1 | VAT1L | VAV1 | VAV2 | VAV3 | VAV3-AS1 | VAX1 | VAX2 | VBP1 | VCAM1 | VCAN | VCL