VAV2: A Potential Drug Target and Biomarker (G7410)

Target Name: VAV2

NCBI ID: G7410

VAV2: A Potential Drug Target and Biomarker

VAV2 (VAV2-HUMAN), a protein that belongs to the Val domain interacting molecule (VAV) family, has been identified as a potential drug target and biomarker in various diseases, including cancer, neurodegenerative diseases, and autoimmune disorders. Its unique structure and function make it an attractive target for drug development, as it can modulate the activity of multiple cellular signaling pathways.

The Val domain interacting molecule (VAV) family plays a crucial role in various cellular processes, including cell signaling, DNA replication, and virus replication. The VAV2 protein is a member of this family and has been shown to interact with multiple cellular signaling pathways , including the TGF-β pathway, the PI3K/Akt signaling pathway, and the NF-kappa-B signaling pathway.

One of the most significant functions of VAV2 is its role in cell signaling. VAV2 has been shown to play a role in several signaling pathways, including the TGF-β pathway, which is involved in cell growth, differentiation, and survival. The TGF- 尾 pathway is a well-established target for numerous diseases, including cancer, and VAV2 has been shown to modulate its activity in these diseases.

In addition to its role in cell signaling, VAV2 has also been shown to play a role in the regulation of cellular processes that are critical for the survival of neurons, including cell survival, neurogenesis, and synaptic plasticity. These functions make VAV2 an attractive target for neurodegenerative diseases, including Alzheimer's disease, Parkinson's disease, and Huntington's disease.

VAV2 has also been shown to play a role in the regulation of cellular immune responses, which are critical for the immune system's ability to detect and eliminate pathogens from the body. These functions make VAV2 an attractive target for the development of vaccines and the treatment of autoimmune disorders.

The VAV2 protein is also a good candidate for a biomarker in cancer, as its expression has been shown to be increased in various types of cancer. This makes VAV2 a potentially useful biomarker for the diagnosis and treatment of cancer.

In conclusion, VAV2 is a protein that has the potential to be a drug target or biomarker for a variety of diseases. Its unique structure and function make it an attractive target for drug development, as it can modulate the activity of multiple cellular signaling pathways. Further research is needed to fully understand the role of VAV2 in these diseases and to develop effective treatments.

Protein Name: Vav Guanine Nucleotide Exchange Factor 2

Functions: Guanine nucleotide exchange factor for the Rho family of Ras-related GTPases. Plays an important role in angiogenesis. Its recruitment by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial cell migration and assembly (By similarity)

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