Studies Show VCPIP1 Interacts with NET and Potential Therapeutic Benefits

Target Name: VCPIP1

NCBI ID: G80124

Other Name(s): deubiquitinating protein VCIP135 | Deubiquitinating protein VCIP135 | Deubiquitinating protein VCPIP1 | DUBA3 | valosin containing protein interacting protein 1 | Valosin-containing protein p97/p47 complex-interacting protein 1 | VCIP135 | Valosin containing protein interacting protein 1 | VCIP1_HUMAN | KIAA1850 | Valosin-containing protein p97/p47 complex-interacting protein p135 | Valosin-containing protein (p97)/p47 complex-interacting protein p135 | valosin-containing protein p97/p47 complex-interacting protein 1 | valosin-containing protein p97/p47 complex-interacting protein p135 | VCP/p47 complex-interacting 135-kDa protein

Studies Show VCPIP1 Interacts with NET and Potential Therapeutic Benefits

VCPIP1 (deubiquitinating protein VCIP135) is a protein that is expressed in various tissues throughout the body, including the brain, heart, and kidneys. It is a key player in the process of protein degradation and has been shown to play a role in a number of cellular processes.

One of the unique features of VCPIP1 is its ability to interact with other proteins and molecules, including the protein known as N-end tachyphylaxis (NET), which is a protein that is involved in the formation of neural connections in the brain. Studies have shown that VCPIP1 and NET can interact with each other and that this interaction may be important for the proper functioning of the brain.

In addition to its role in the brain, VCPIP1 has also been shown to be involved in a number of other cellular processes, including the regulation of protein levels and the detoxification of harmful substances. It is also involved in the development and maintenance of the immune system, which is important for protecting the body against infection and disease.

Given its involvement in a number of important cellular processes, VCPIP1 has been considered as a potential drug target or biomarker. Studies have shown that blocking the activity of VCPIP1 has been shown to have a number of potential therapeutic benefits, including the treatment of a variety of diseases, such as cancer, neurodegenerative diseases, and autoimmune disorders.

In addition to its potential therapeutic uses, VCPIP1 has also been shown to be a valuable research tool. Studies have shown that VCPIP1 can be used to study the structure and function of other proteins, as well as the interactions between different proteins and molecules. This has important implications for our understanding of the underlying mechanisms of many diseases.

Overall, VCPIP1 is a protein that has important roles in a number of cellular processes and has been shown to be involved in the development and maintenance of a number of important tissues and organs. As a result, it is a promising target for drug development and research.

Protein Name: Valosin Containing Protein Interacting Protein 1

Functions: Deubiquitinating enzyme involved in DNA repair and reassembly of the Golgi apparatus and the endoplasmic reticulum following mitosis (PubMed:32649882). Necessary for VCP-mediated reassembly of Golgi stacks after mitosis (By similarity). Plays a role in VCP-mediated formation of transitional endoplasmic reticulum (tER) (By similarity). Mediates dissociation of the ternary complex containing STX5A, NSFL1C and VCP (By similarity). Also involved in DNA repair following phosphorylation by ATM or ATR: acts by catalyzing deubiquitination of SPRTN, thereby promoting SPRTN recruitment to chromatin and subsequent proteolytic cleavage of covalent DNA-protein cross-links (DPCs) (PubMed:32649882). Hydrolyzes 'Lys-11'- and 'Lys-48'-linked polyubiquitin chains (PubMed:23827681)

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