VPS36: A Protein Involved in Cellular Processes and Disease (G51028)

Target Name: VPS36

NCBI ID: G51028

VPS36: A Protein Involved in Cellular Processes and Disease

VPS36 (Virtual Personalized Systematic Resource) is a protein that is expressed in various tissues and organs in the body. It is a subunit of the ESCRT-II complex, which is a protein that helps to protect cells from apoptosis, or programmed cell death. This protein is of interest because it has been shown to be involved in a variety of cellular processes, including cell signaling, cell division, and stress responses. As a result, VPS36 may be a drug target or biomarker for a variety of diseases.

One of the functions of VPS36 is to regulate the activity of the ESCRT-II complex. This complex is made up of a variety of proteins that work together to help protect cells from apoptosis. VPS36 is one of the subunits of this complex, and it is responsible for helping to regulate the activity of the other subunits. This is important because when cells are exposed to stress or damage, the ESCRT-II complex helps to protect them from apoptosis. If VPS36 is not functioning properly, it can lead to apoptosis, which can be a hallmark of a variety of diseases.

In addition to its role in regulating the ESCRT-II complex, VPS36 is also involved in a variety of other cellular processes. For example, it has been shown to be involved in cell signaling, cell division, and stress responses. VPS36 has been shown to play a role in the regulation of cell proliferation, and it has been shown to help control the amount of DNA that is replicated in cells. It is also involved in the regulation of cell stress responses, and has been shown to help protect cells from the effects of stress.

VPS36 may also be of interest as a drug target or biomarker because it is thought to be involved in the development and progression of a variety of diseases. For example, VPS36 has been shown to be involved in the development of cancer, and may be a useful target for cancer therapies. It is also thought to be involved in the development of neurodegenerative diseases, and may be a useful target for therapies aimed at these conditions.

In conclusion, VPS36 is a protein that is expressed in various tissues and organs in the body. It is a subunit of the ESCRT-II complex, and is involved in a variety of cellular processes. As a result, VPS36 may be a drug target or biomarker for a variety of diseases. Further research is needed to fully understand its role in these processes and to determine its potential as a therapeutic target.

Protein Name: Vacuolar Protein Sorting 36 Homolog

Functions: Component of the ESCRT-II complex (endosomal sorting complex required for transport II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs. The MVB pathway mediates delivery of transmembrane proteins into the lumen of the lysosome for degradation. The ESCRT-II complex is probably involved in the recruitment of the ESCRT-III complex. Its ability to bind ubiquitin probably plays a role in endosomal sorting of ubiquitinated cargo proteins by ESCRT complexes. The ESCRT-II complex may also play a role in transcription regulation, possibly via its interaction with ELL. Binds phosphoinosides such as PtdIns(3,4,5)P3

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