Target Name: WAS
NCBI ID: G7454
Other Name(s): WASP | Wiskott-Aldrich syndrome protein | Actin nucleation-promoting factor WAS | WASP_HUMAN | thrombocytopenia 1 (X-linked) | WASP actin nucleation promoting factor | WASPA | Wiskott-Aldrich syndrome (eczema-thrombocytopenia) protein | THC | eczema-thrombocytopenia | WASp | SCNX | THC1 | IMD2

WASP: A Protein Involved in Cell Signaling and Disease

WAS (WASP), also known as wiskott-aspartic acid receptor (WASP) or Fc portion of the immunoglobulin (Fc-Ig), is a protein that is expressed in many tissues throughout the body. It is a type of transmembrane protein that is composed of an extracellular domain, a transmembrane region, and an intracellular domain. The extracellular domain of WASP contains a N-terminus that is involved in cell adhesion and signaling, while the transmembrane region contains a series of immunoglobulin-like domains (Ig -like domains) that are involved in cell signaling and interactions. The intracellular domain of WASP contains a series of unique structural features that are involved in intracellular signaling and interactions.

One of the unique features of WASP is its ability to interact with other proteins and molecules. WASP has multiple interacting partners, including several different signaling pathways, such as the PI3K/Akt signaling pathway, the TGF-β signaling pathway, and the NF-kappa-B signaling pathway. These interactions are important for the regulation of various cellular processes, including cell signaling, cell adhesion, and inflammation.

WASP has also been shown to play a role in the development and progression of various diseases, including cancer, autoimmune diseases, and neurodegenerative diseases. For example, WASP has been shown to be involved in the regulation of cancer cell growth and survival, and has has been identified as a potential drug target for various diseases.

In addition to its role in disease, WASP has also been shown to have potential as a drug target. WASP has been shown to interact with various signaling pathways and proteins, making it a potential target for small molecules, antibodies, and other therapeutic agents. For example, several studies have shown that small molecules can interact with WASP and enhance its signaling activity, leading to potential therapeutic benefits.

Overall, WASP is a protein that has significant implications for the regulation of various cellular processes and has been shown to play a role in the development and progression of various diseases. As a drug target, WASP is a promising target for small molecules and other therapeutic agents that can be used to treat a variety of diseases.

Protein Name: WASP Actin Nucleation Promoting Factor

Functions: Effector protein for Rho-type GTPases that regulates actin filament reorganization via its interaction with the Arp2/3 complex (PubMed:12235133, PubMed:12769847, PubMed:16275905). Important for efficient actin polymerization (PubMed:8625410, PubMed:12235133, PubMed:16275905). Possible regulator of lymphocyte and platelet function (PubMed:9405671). Mediates actin filament reorganization and the formation of actin pedestals upon infection by pathogenic bacteria (PubMed:18650809). In addition to its role in the cytoplasmic cytoskeleton, also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA (PubMed:20574068). Promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs) (PubMed:29925947)

More Common Targets

WASF1 | WASF2 | WASF3 | WASF4P | WASF5P | WASH complex | WASH2P | WASH3P | WASH4P | WASH5P | WASH6P | WASH7P | WASH8P | WASHC1 | WASHC2A | WASHC2C | WASHC3 | WASHC4 | WASHC5 | WASIR1 | WASL | WAVE1 complex | WBP1 | WBP11 | WBP11P1 | WBP1L | WBP2 | WBP2NL | WBP4 | WDCP | WDFY1 | WDFY2 | WDFY3 | WDFY3-AS2 | WDFY4 | WDHD1 | WDPCP | WDR1 | WDR11 | WDR11-DT | WDR12 | WDR13 | WDR17 | WDR18 | WDR19 | WDR20 | WDR24 | WDR25 | WDR26 | WDR27 | WDR3 | WDR31 | WDR33 | WDR35 | WDR35-DT | WDR36 | WDR37 | WDR38 | WDR4 | WDR41 | WDR43 | WDR44 | WDR45 | WDR45B | WDR46 | WDR47 | WDR48 | WDR49 | WDR5 | WDR53 | WDR54 | WDR55 | WDR59 | WDR5B | WDR6 | WDR62 | WDR64 | WDR7 | WDR70 | WDR72 | WDR73 | WDR74 | WDR75 | WDR76 | WDR77 | WDR81 | WDR82 | WDR82P1 | WDR83 | WDR83OS | WDR86 | WDR86-AS1 | WDR87 | WDR88 | WDR89 | WDR90 | WDR91 | WDR93 | WDR97 | WDSUB1