Target Name: WDR1
NCBI ID: G9948
Other Name(s): WD repeat-containing protein 1 (isoform 2) | actin-interacting protein 1 | Actin-interacting protein 1 (AIP1) | WD repeat-containing protein 1 (isoform 1) | HEL-S-52 | WD repeat domain 1, transcript variant 1 | WDR1 variant 2 | WD repeat-containing protein 1 | AIP1 | WD repeat domain 1, transcript variant 2 | Actin-interacting protein 1 | WDR1_HUMAN | epididymis secretory protein Li 52 | WDR1 variant 1 | PFITS | NORI-1 | WD repeat domain 1

WDR1: Potential Drug Target and Regulator of Cellular Processes

WDR1 (Wiskott-Aldrich repeat containing protein 1) is a protein that is expressed in many different tissues throughout the body. It is a member of the Wiskott-Aldrich repeat protein family, which is a type of transmembrane protein that is characterized by the presence of a Wiskott-Aldrich repeat in the extracellular domain.

WDR1 is involved in many different cellular processes in the body, including cell signaling, cell adhesion, and transcriptional regulation. It is a key regulator of the T cell receptor signaling pathway, which is responsible for the development and activation of T cells.

WDR1 has also been shown to play a role in the development and progression of various diseases, including cancer. For example, studies have shown that high levels of WDR1 are associated with poor prognosis in patients with pancreatic cancer, and that inhibiting WDR1 has been shown to be a promising strategy for treating this disease.

In addition to its role in cancer, WDR1 is also a potential drug target. Several studies have shown that WDR1 can be targeted by small molecules, including inhibitors of tyrosine kinase activity. These inhibitors have been shown to inhibit the activity of the TCR signaling pathway, which is a key regulator of cell growth and differentiation.

In conclusion, WDR1 is a protein that is involved in many different cellular processes in the body. Its role in cell signaling, cell adhesion, and transcriptional regulation makes it a potential drug target. Furthermore, its association with cancer and poor prognosis makes it an attractive target for small molecule inhibitors. Further research is needed to fully understand the role of WDR1 in the development and progression of disease.

Protein Name: WD Repeat Domain 1

Functions: Induces disassembly of actin filaments in conjunction with ADF/cofilin family proteins (PubMed:15629458, PubMed:27557945, PubMed:29751004). Enhances cofilin-mediated actin severing (By similarity). Involved in cytokinesis. Involved in chemotactic cell migration by restricting lamellipodial membrane protrusions (PubMed:18494608). Involved in myocardium sarcomere organization. Required for cardiomyocyte growth and maintenance (By similarity). Involved in megakaryocyte maturation and platelet shedding. Required for the establishment of planar cell polarity (PCP) during follicular epithelium development and for cell shape changes during PCP; the function seems to implicate cooperation with CFL1 and/or DSTN/ADF. Involved in the generation/maintenance of cortical tension (By similarity). Involved in assembly and maintenance of epithelial apical cell junctions and plays a role in the organization of the perijunctional actomyosin belt (PubMed:25792565)

More Common Targets

WDR11 | WDR11-DT | WDR12 | WDR13 | WDR17 | WDR18 | WDR19 | WDR20 | WDR24 | WDR25 | WDR26 | WDR27 | WDR3 | WDR31 | WDR33 | WDR35 | WDR35-DT | WDR36 | WDR37 | WDR38 | WDR4 | WDR41 | WDR43 | WDR44 | WDR45 | WDR45B | WDR46 | WDR47 | WDR48 | WDR49 | WDR5 | WDR53 | WDR54 | WDR55 | WDR59 | WDR5B | WDR6 | WDR62 | WDR64 | WDR7 | WDR70 | WDR72 | WDR73 | WDR74 | WDR75 | WDR76 | WDR77 | WDR81 | WDR82 | WDR82P1 | WDR83 | WDR83OS | WDR86 | WDR86-AS1 | WDR87 | WDR88 | WDR89 | WDR90 | WDR91 | WDR93 | WDR97 | WDSUB1 | WDTC1 | WEE1 | WEE2 | WEE2-AS1 | WFDC1 | WFDC10A | WFDC10B | WFDC11 | WFDC12 | WFDC13 | WFDC2 | WFDC21P | WFDC3 | WFDC5 | WFDC6 | WFDC8 | WFDC9 | WFIKKN1 | WFIKKN2 | WFS1 | WHAMM | WHAMMP1 | WHAMMP2 | WHAMMP3 | WHRN | WIF1 | WIPF1 | WIPF2 | WIPF3 | WIPI1 | WIPI2 | WIZ | WLS | WNK1 | WNK2 | WNK3 | WNK4 | Wnt