Target Name: WDR74
NCBI ID: G54663
Other Name(s): FLJ10439 | Nsa1 | WD repeat-containing protein 74 | WD repeat domain 74, transcript variant 1 | NSA1 | NOP seven-associated protein 1 | WD repeat domain 74 | WDR74_HUMAN | WDR74 variant 1 | WD repeat-containing protein 74 (isoform 1) | FLJ21730

WDR74: A Drug Target / Disease Biomarker

WDR74, also known as WDR74-1, is a protein that is expressed in various tissues throughout the body, including the brain, pancreas, and gastrointestinal tract. It is a member of the WDR family, which includes several similar proteins that are involved in cell-signaling pathways.

WDR74 is unique due to its ability to interact with several different signaling pathways, including the TGF-β pathway and the NF-kappa-B pathway. This makes it a promising drug target for a variety of diseases.

One of the ways that WDR74 interacts with the TGF-β pathway is through its ability to regulate the activity of the transcription factor, SMAD1. SMAD1 is a key regulator of TGF-β signaling, and is involved in the development and maintenance of tissues. WDR74 has been shown to physically interact with SMAD1 and to regulate its activity.

Another way that WDR74 interacts with the TGF-β pathway is through its role in the regulation of cell-padding, a process that is important for tissue repair and regeneration. WDR74 has been shown to be involved in the regulation of cell-padding in various tissues, including the brain and the pancreas.

WDR74 is also involved in the regulation of the NF-kappa-B pathway, a signaling pathway that is important for inflammation and immune responses. The NF-kappa-B pathway is involved in the regulation of a wide range of physiological processes, including inflammation, pain, and cell growth. WDR74 has been shown to be involved in the regulation of NF-kappa-B signaling in various tissues.

In addition to its role in cell-signaling pathways, WDR74 is also of interest as a potential biomarker for several diseases. For example, it has been shown to be involved in the regulation of insulin secretion from pancreatic beta cells, which may be an important biomarker for the development of type 2 diabetes.

WDR74 is also of interest as a potential drug target for several diseases, including cancer, neurodegenerative diseases, and autoimmune diseases. For example, it has been shown to be involved in the regulation of cancer cell growth and survival, which may make it an attractive target for cancer therapies.

In conclusion, WDR74 is a protein that is involved in a variety of cell-signaling pathways and has been shown to be involved in the regulation of insulin secretion, cell-padding, and cancer cell growth. As a result, it is a promising drug target for a variety of diseases. Further research is needed to fully understand the role of WDR74 in these processes and to develop effective therapies.

Protein Name: WD Repeat Domain 74

Functions: Regulatory protein of the MTREX-exosome complex involved in the synthesis of the 60S ribosomal subunit (PubMed:26456651). Participates in an early cleavage of the pre-rRNA processing pathway in cooperation with NVL (PubMed:29107693). Required for blastocyst formation, is necessary for RNA transcription, processing and/or stability during preimplantation development (By similarity)

More Common Targets

WDR75 | WDR76 | WDR77 | WDR81 | WDR82 | WDR82P1 | WDR83 | WDR83OS | WDR86 | WDR86-AS1 | WDR87 | WDR88 | WDR89 | WDR90 | WDR91 | WDR93 | WDR97 | WDSUB1 | WDTC1 | WEE1 | WEE2 | WEE2-AS1 | WFDC1 | WFDC10A | WFDC10B | WFDC11 | WFDC12 | WFDC13 | WFDC2 | WFDC21P | WFDC3 | WFDC5 | WFDC6 | WFDC8 | WFDC9 | WFIKKN1 | WFIKKN2 | WFS1 | WHAMM | WHAMMP1 | WHAMMP2 | WHAMMP3 | WHRN | WIF1 | WIPF1 | WIPF2 | WIPF3 | WIPI1 | WIPI2 | WIZ | WLS | WNK1 | WNK2 | WNK3 | WNK4 | Wnt | WNT1 | WNT10A | WNT10B | WNT11 | WNT16 | WNT2 | WNT2B | WNT3 | WNT3A | WNT4 | WNT5A | WNT5B | WNT6 | WNT7A | WNT7B | WNT8A | WNT8B | WNT9A | WNT9B | WRAP53 | WRAP73 | WRN | WRNIP1 | WSB1 | WSB2 | WSCD1 | WSCD2 | WSPAR | WT1 | WT1-AS | WTAP | WTAPP1 | WTIP | WWC1 | WWC2 | WWC2-AS2 | WWC3 | WWOX | WWP1 | WWP2 | WWTR1 | WWTR1-AS1 | XAB2 | XACT