WDR81: A Potential Drug Target and Biomarker for Cancer (G124997)

Target Name: WDR81

NCBI ID: G124997

WDR81: A Potential Drug Target and Biomarker for Cancer

WDR81, also known as WDR81 variant 1, is a non-coding RNA molecule that has been identified as a potential drug target and biomarker for various diseases, including cancer. Its unique structure and function make it an attractive target for researchers to study and develop new treatments.

WDR81 is a long non-coding RNA molecule that is found in many different cell types. It is made up of 21 RNA domains, each of which has a unique structure and function. The most studied WDR81 variant is WDR81 variant 1, which is a unique isoform that contains the N-terminus of WDR81 and a unique intron exon.

WDR81 variant 1 has been shown to play a role in various diseases, including cancer. Studies have shown that high levels of WDR81 variant 1 are associated with poor prognosis in cancer patients. Additionally, experiments have shown that inhibiting WDR81 variant 1 can lead to regression of cancer tumors in animal models.

One of the reasons why WDR81 variant 1 is considered a potential drug target is its unique structure. Unlike many other non-coding RNAs, WDR81 variant 1 has a clear and defined beginning and end, making it easier to study and develop new treatments. Additionally , its unique sequence allows researchers to identify specific parts of the molecule that are responsible for its function and to target those areas with drugs.

Another potential drug target for WDR81 variant 1 is its expression pattern. Studies have shown that WDR81 variant 1 is expressed in many different tissues and cells, including those that are affected by cancer. This makes it an attractive target for drugs that can inhibit its expression and reduce the risk of cancer progression.

In addition to its potential as a drug target, WDR81 variant 1 is also a potential biomarker. Its unique structure and function make it an attractive target for RNA-based diagnostic tests. Studies have shown that WDR81 variant 1 can be used as a primer to detect cancer-specific genes and that its levels can be used as a biomarker for cancer diagnosis and monitoring.

Overall, WDR81 variant 1 is a promising drug target and biomarker for cancer. Its unique structure and function make it an attractive target for drugs that can inhibit its expression and promote its degradation. Further research is needed to fully understand its role in cancer and to develop new treatments based on its unique properties.

Protein Name: WD Repeat Domain 81

Functions: Functions as a negative regulator of the PI3 kinase/PI3K activity associated with endosomal membranes via BECN1, a core subunit of the PI3K complex. By modifying the phosphatidylinositol 3-phosphate/PtdInsP3 content of endosomal membranes may regulate endosome fusion, recycling, sorting and early to late endosome transport (PubMed:26783301). It is for instance, required for the delivery of cargos like BST2/tetherin from early to late endosome and thereby participates indirectly to their degradation by the lysosome (PubMed:27126989). May also play a role in aggrephagy, the macroautophagic degradation of ubiquitinated protein aggregates. In this process, may regulate the interaction of SQSTM1 with ubiquitinated proteins and also recruit MAP1LC3C (PubMed:28404643). May also be involved in maintenance of normal mitochondrial structure and organization (By similarity)

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