Target Name: WDR20
NCBI ID: G91833
Other Name(s): WD repeat-containing protein 20 | DMR | WDR20 variant 1 | Bun107 | WDR20_HUMAN | MGC33183 | Protein DMR | WD repeat domain 20 | WDR20 variant 6 | MGC33177 | WD repeat-containing protein 20 (isoform 1) | WD repeat domain 20, transcript variant 1 | WD repeat domain 20, transcript variant 6 | WD repeat-containing protein 20 (isoform 6) | FLJ33659

WDR20: Key Regulator of Development and Maintenance

WDR20 (Wnt-repeat-containing protein 20) is a protein that is expressed in various tissues throughout the body, including the nervous system, endocrine system, and reproductive system. It is a key regulator of development and maintenance, and is involved in a wide range of physiological processes.

One of the unique features of WDR20 is its ability to repeat a wnt gene, which is a developmental transcription factor that is important for the formation of neural tube and the development of the nervous system. The repeated wnt gene is thought to contribute to the protein's ability to promote the formation of new neurons and the formation of neural connections.

WDR20 is also involved in the regulation of stem cells and their proliferation. It has been shown to play a role in the self-renewal of stem cells and has been shown to be important for the development and maintenance of neural stem cells.

In addition to its role in stem cells, WDR20 is also involved in the regulation of cell survival and death. It has been shown to play a role in the regulation of cell apoptosis, which is the process by which cells die naturally in the body.

WDR20 is also involved in the regulation of inflammation. It has been shown to play a role in the regulation of immune cells, including T cells and macrophages.

In conclusion, WDR20 is a protein that is involved in a wide range of physiological processes, including the regulation of development and maintenance, the regulation of stem cells and their proliferation, the regulation of cell apoptosis, and the regulation of inflammation. As a result , it is a potential drug target and biomarker for a variety of diseases. Further research is needed to fully understand the role of WDR20 in these processes and to develop effective treatments.

Protein Name: WD Repeat Domain 20

Functions: Regulator of deubiquitinating complexes. Activates deubiquitinating activity of complexes containing USP12 (PubMed:20147737, PubMed:27373336). Anchors at the base of the ubiquitin-contacting loop of USP12 and remotely modulates the catalytic center of the enzyme (PubMed:27373336)

More Common Targets

WDR24 | WDR25 | WDR26 | WDR27 | WDR3 | WDR31 | WDR33 | WDR35 | WDR35-DT | WDR36 | WDR37 | WDR38 | WDR4 | WDR41 | WDR43 | WDR44 | WDR45 | WDR45B | WDR46 | WDR47 | WDR48 | WDR49 | WDR5 | WDR53 | WDR54 | WDR55 | WDR59 | WDR5B | WDR6 | WDR62 | WDR64 | WDR7 | WDR70 | WDR72 | WDR73 | WDR74 | WDR75 | WDR76 | WDR77 | WDR81 | WDR82 | WDR82P1 | WDR83 | WDR83OS | WDR86 | WDR86-AS1 | WDR87 | WDR88 | WDR89 | WDR90 | WDR91 | WDR93 | WDR97 | WDSUB1 | WDTC1 | WEE1 | WEE2 | WEE2-AS1 | WFDC1 | WFDC10A | WFDC10B | WFDC11 | WFDC12 | WFDC13 | WFDC2 | WFDC21P | WFDC3 | WFDC5 | WFDC6 | WFDC8 | WFDC9 | WFIKKN1 | WFIKKN2 | WFS1 | WHAMM | WHAMMP1 | WHAMMP2 | WHAMMP3 | WHRN | WIF1 | WIPF1 | WIPF2 | WIPF3 | WIPI1 | WIPI2 | WIZ | WLS | WNK1 | WNK2 | WNK3 | WNK4 | Wnt | WNT1 | WNT10A | WNT10B | WNT11 | WNT16 | WNT2 | WNT2B | WNT3