Target Name: WDR5
NCBI ID: G11091
Other Name(s): cilia and flagella associated protein 89 | OTTHUMP00000162494 | BIG-3 | WDR5 variant 2 | WD repeat-containing protein 5 (isoform 1) | SWD3 | WDR5 variant 1 | WD-repeat protein 5 | WD repeat-containing protein 5 | CFAP89 | WD repeat domain 5, transcript variant 2 | WD repeat domain 5, transcript variant 1 | SWD3, Set1c WD40 repeat protein, homolog | BIG3 | WDR5_HUMAN | BMP2-induced 3-kb gene protein | WD repeat domain 5

WDR5 as A Drug Target and Biomarker

Cilia and flagella associated protein 89 (WDR5) is a protein that is expressed in the cilia, which are small hair-like structures that line the surface of the body's various body systems. WDR5 is a key regulator of the cilia, and it is involved in the proper functioning of the cilia's mechanical properties.

Recent studies have suggested that WDR5 may be a drug target or biomarker, due to its involvement in the regulation of cilia function and its potential role in the development of various diseases. In this article, we will explore the potential implications of WDR5 as a drug target and biomarker, and discuss some of the recent research that has identified its potential in this context.

The cilia are small structures that line the surface of various body systems, including the lungs, the eyes, and the digestive system. They are composed of a single layer of ciliated epithelial cells that are joined at their ends by thin extensions called cilia links. The cilia are responsible for moving small particles, such as bacteria and other microorganisms, out of the body's various body systems.

WDR5 is a key regulator of the cilia's mechanical properties. It is a protein that is expressed in the cilia and is involved in the proper functioning of the cilia's mechanical properties. Studies have shown that WDR5 plays a key role in regulating the extension and retraction of the cilia links, as well as the overall structure and function of the cilia.

Recent studies have suggested that WDR5 may be a drug target or biomarker due to its involvement in the regulation of cilia function and its potential role in the development of various diseases. For example, studies have shown that WDR5 may be a potential drug target for the treatment of various respiratory diseases, including chronic obstructive pulmonary disease (COPD) and asthma.

In addition to its potential as a drug target, WDR5 has also been identified as a potential biomarker for the evaluation of various diseases. For example, studies have shown that levels of WDR5 have been elevated in the lungs of individuals with COPD, and that these levels were associated with decreased cilia function. Similarly, levels of WDR5 have been shown to be elevated in the lungs of individuals with asthma, and that these levels were associated with decreased cilia function.

In conclusion, Cilia and flagella associated protein 89 (WDR5) is a protein that is expressed in the cilia and is involved in the proper functioning of the cilia's mechanical properties. Recent studies have suggested that WDR5 may be a drug target or biomarker, due to its involvement in the regulation of cilia function and its potential role in the development of various diseases. Further research is needed to fully understand the potential implications of WDR5 as a drug target and biomarker.

Protein Name: WD Repeat Domain 5

Functions: Contributes to histone modification (PubMed:19131338, PubMed:19556245, PubMed:19103755, PubMed:20018852, PubMed:16600877, PubMed:16829960). May position the N-terminus of histone H3 for efficient trimethylation at 'Lys-4' (PubMed:16829960). As part of the MLL1/MLL complex it is involved in methylation and dimethylation at 'Lys-4' of histone H3 (PubMed:19556245). H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation (PubMed:18840606). As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues (PubMed:19103755, PubMed:20018852). May regulate osteoblasts differentiation (By similarity). In association with RBBP5 and ASH2L, stimulates the histone methyltransferase activities of KMT2A, KMT2B, KMT2C, KMT2D, SETD1A and SETD1B (PubMed:21220120, PubMed:22266653)

More Common Targets

WDR53 | WDR54 | WDR55 | WDR59 | WDR5B | WDR6 | WDR62 | WDR64 | WDR7 | WDR70 | WDR72 | WDR73 | WDR74 | WDR75 | WDR76 | WDR77 | WDR81 | WDR82 | WDR82P1 | WDR83 | WDR83OS | WDR86 | WDR86-AS1 | WDR87 | WDR88 | WDR89 | WDR90 | WDR91 | WDR93 | WDR97 | WDSUB1 | WDTC1 | WEE1 | WEE2 | WEE2-AS1 | WFDC1 | WFDC10A | WFDC10B | WFDC11 | WFDC12 | WFDC13 | WFDC2 | WFDC21P | WFDC3 | WFDC5 | WFDC6 | WFDC8 | WFDC9 | WFIKKN1 | WFIKKN2 | WFS1 | WHAMM | WHAMMP1 | WHAMMP2 | WHAMMP3 | WHRN | WIF1 | WIPF1 | WIPF2 | WIPF3 | WIPI1 | WIPI2 | WIZ | WLS | WNK1 | WNK2 | WNK3 | WNK4 | Wnt | WNT1 | WNT10A | WNT10B | WNT11 | WNT16 | WNT2 | WNT2B | WNT3 | WNT3A | WNT4 | WNT5A | WNT5B | WNT6 | WNT7A | WNT7B | WNT8A | WNT8B | WNT9A | WNT9B | WRAP53 | WRAP73 | WRN | WRNIP1 | WSB1 | WSB2 | WSCD1 | WSCD2 | WSPAR | WT1 | WT1-AS | WTAP