Target Name: WDR59
NCBI ID: G79726
Other Name(s): FP977 | CDW12 | WD repeat-containing protein 59 | GATOR complex protein WDR59 (isoform 1) | WD repeat domain 59, transcript variant 1 | GATOR complex protein WDR59 | CDw12 antigen | p90-120 | WDR59_HUMAN | WD repeat domain 59 | WDR59 variant 1 | KIAA1923

WDR59: A Protein Implicated in Cell Adhesion, Survival and Migration

WDR59 (FP977) is a protein that is expressed in various tissues of the body, including the brain, heart, and gastrointestinal tract. It is a member of the WDR family, which includes several similar proteins that are involved in various cellular processes. One of the unique features of WDR59 is its ability to interact with the protein p120GAP, which is a negative regulator of the exchange factor tyrosine-protein kinase (TK).

In recent years, the study of WDR59 has highlighted its potential as a drug target and biomarker. Several studies have demonstrated that modulating the activity of WDR59 can have a significant impact on various cellular processes, including cell survival, migration, and angiogenesis.

One of the key mechanisms by which WDR59 is involved in these processes is its role in the regulation of cell adhesion. WDR59 is a component of the adherens junction, which is a complex that forms the tight junctions between adjacent cells. This structure is critical for maintaining tissue architecture and for ensuring the proper functioning of various organs and tissues.

Several studies have shown that WDR59 plays a critical role in the regulation of cell adhesion by interacting with the protein zeb2 (also known as CD103). Zeb2 is a scaffold protein that is involved in the formation of tight junctions and in the regulation of cell-cell adhesion. WDR59 has been shown to physically interact with zeb2 and to modulate the activity of zeb2.

In addition to its role in cell adhesion, WDR59 is also involved in the regulation of cell survival and migration. Several studies have shown that WDR59 can interact with the protein Bcl-2 (also known as PDZ-L1) and to modulate the activity of Bcl-2. Bcl-2 is a protein that is involved in the regulation of cell growth and differentiation, and its activity is regulated by a variety of factors, including WDR59.

WDR59 has also been shown to be involved in the regulation of angiogenesis, the process by which new blood vessels are formed. Several studies have shown that WDR59 can interact with the protein Notch (also known as JAG1), which is involved in the regulation of angiogenesis. Notch is a transmembrane protein that is involved in the regulation of various cellular processes, including cell adhesion and angiogenesis.

In conclusion, WDR59 is a protein that is involved in various cellular processes and has been shown to play a critical role in the regulation of cell adhesion, survival, and migration. Its potential as a drug target and biomarker makes it an attractive target for researchers to investigate further. Further studies are needed to fully understand the mechanisms by which WDR59 is involved in these processes and to determine its potential as a therapeutic agent.

Protein Name: WD Repeat Domain 59

Functions: As a component of the GATOR subcomplex GATOR2, functions within the amino acid-sensing branch of the TORC1 signaling pathway. Indirectly activates mTORC1 and the TORC1 signaling pathway through the inhibition of the GATOR1 subcomplex (PubMed:23723238). It is negatively regulated by the upstream amino acid sensors SESN2 and CASTOR1 (PubMed:25457612, PubMed:27487210)

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