Target Name: WASHC2A
NCBI ID: G387680
Other Name(s): WASH complex subunit FAM21B | FAM21B | FAM21A | bA98I6.1 | WASH complex subunit 2A, transcript variant 1 | family with sequence similarity 21, member B | alternative protein FAM21B | WASH complex subunit FAM21A | family with sequence similarity 21 member A | WAC2A_HUMAN | WASHC2A variant 1 | WASH complex subunit 2A | bA56A21.1 | WASH complex subunit 2A (isoform 1)

Understanding Washc2a: A Protein Involved in Cell Adhesion and Disease Regulation

Washc2a, also known as WASP-2, is a protein that belongs to the WASP-2 family of proteins. It is a 21 kDa protein that is expressed in various tissues of the body, including the brain, heart, and lungs. washc2a plays a crucial role in the regulation of cell adhesion, which is the process by which cells stick together to form tissues and organs.

One of the most interesting aspects of washc2a is its potential as a drug target. washc2a has been shown to be involved in a wide range of physiological processes that are important for human health, including the development and progression of cancer, neurodegenerative diseases, and autoimmune disorders. As a result, washc2a has become a focus of research in the field of drug discovery, with many teams working to identify and develop compounds that can modulate washc2a activity.

One of the key challenges in studying washc2a as a drug target is its complex structure. washc2a is a protein that contains multiple domains, including an N-terminal transmembrane domain, a coiled-coil domain, and a C-terminal T-loop domain. The transmembrane domain is responsible for the protein's ability to interact with the cell membrane, while the coiled-coil domain is responsible for the protein's ability to adopt a specific shape. The T-loop domain is involved in the regulation of the protein's stability and functions as a negative regulator.

In recent years, researchers have made significant progress in the study of washc2a's structure and function. One of the most significant findings is that the N-terminal transmembrane domain of washc2a contains a putative regulatory domain that is involved in the regulation of the protein's stability. This domain is composed of a series of amino acids that are involved in a hydrogen bonding network and are thought to play a role in the regulation of the protein's stability.

Another important finding is that the coiled-coil domain of washc2a is involved in the regulation of cell adhesion. This is thought to be because the coiled-coil domain is able to interact with the cell membrane and influence the distribution of the protein throughout the cell. Recent studies have shown that the coiled-coil domain of washc2a is able to interact with several different molecules, including the protein ZF-217, which is involved in the regulation of cell adhesion.

The C-terminal T-loop domain of washc2a is involved in the regulation of the protein's stability and functions as a negative regulator. This domain is composed of a series of amino acids that are involved in a hydrogen bonding network and are thought to play a role in the regulation of the protein's stability.

Despite the many advances in our understanding of washc2a, there is still much to be learned about its function and potential as a drug target. One of the most promising areas of research is the study of washc2a's role in the regulation of cancer progression. washc2a has been shown to be involved in the regulation of cell division and the development of cancer, and as a result, it is thought to be a potential drug target for cancer therapies.

Another promising area of research is the study of washc2a's role in neurodegenerative diseases. washc2a has been shown to be involved in the regulation of the formation of neurotransmitter receptors, which are important for the transmission of signals throughout the nervous system. As a result, it is thought to be involved in the development and progression of neurodegenerative diseases.

In addition, washc2a is also a potential biomarker for certain diseases, such as cancer, neurodegenerative diseases, and autoimmune disorders. Its expression and function have been shown to be altered in a wide range of diseases, which suggests that it may be a useful indicator of disease status.

In conclusion, washc2a is a complex protein that plays a crucial role in the regulation of cell adhesion and the development and progression of various diseases. Its structure and function have been studied extensively in recent years, and as a result, it has become a focus of

Protein Name: WASH Complex Subunit 2A

Functions: Acts at least in part as component of the WASH core complex whose assembly at the surface of endosomes inhibits WASH nucleation-promoting factor (NPF) activity in recruiting and activating the Arp2/3 complex to induce actin polymerization and is involved in the fission of tubules that serve as transport intermediates during endosome sorting. Mediates the recruitment of the WASH core complex to endosome membranes via binding to phospholipids and VPS35 of the retromer CSC. Mediates the recruitment of the F-actin-capping protein dimer to the WASH core complex probably promoting localized F-actin polymerization needed for vesicle scission. Via its C-terminus binds various phospholipids, most strongly phosphatidylinositol 4-phosphate (PtdIns-(4)P), phosphatidylinositol 5-phosphate (PtdIns-(5)P) and phosphatidylinositol 3,5-bisphosphate (PtdIns-(3,5)P2). Involved in the endosome-to-plasma membrane trafficking and recycling of SNX27-retromer-dependent cargo proteins, such as GLUT1. Required for the association of DNAJC13, ENTR1, ANKRD50 with retromer CSC subunit VPS35. Required for the endosomal recruitment of CCC complex subunits COMMD1 and CCDC93 as well as the retriever complex subunit VPS35L

More Common Targets

WASHC2C | WASHC3 | WASHC4 | WASHC5 | WASIR1 | WASL | WAVE1 complex | WBP1 | WBP11 | WBP11P1 | WBP1L | WBP2 | WBP2NL | WBP4 | WDCP | WDFY1 | WDFY2 | WDFY3 | WDFY3-AS2 | WDFY4 | WDHD1 | WDPCP | WDR1 | WDR11 | WDR11-DT | WDR12 | WDR13 | WDR17 | WDR18 | WDR19 | WDR20 | WDR24 | WDR25 | WDR26 | WDR27 | WDR3 | WDR31 | WDR33 | WDR35 | WDR35-DT | WDR36 | WDR37 | WDR38 | WDR4 | WDR41 | WDR43 | WDR44 | WDR45 | WDR45B | WDR46 | WDR47 | WDR48 | WDR49 | WDR5 | WDR53 | WDR54 | WDR55 | WDR59 | WDR5B | WDR6 | WDR62 | WDR64 | WDR7 | WDR70 | WDR72 | WDR73 | WDR74 | WDR75 | WDR76 | WDR77 | WDR81 | WDR82 | WDR82P1 | WDR83 | WDR83OS | WDR86 | WDR86-AS1 | WDR87 | WDR88 | WDR89 | WDR90 | WDR91 | WDR93 | WDR97 | WDSUB1 | WDTC1 | WEE1 | WEE2 | WEE2-AS1 | WFDC1 | WFDC10A | WFDC10B | WFDC11 | WFDC12 | WFDC13 | WFDC2 | WFDC21P | WFDC3 | WFDC5 | WFDC6