Targeting VWF-A Using Small Molecules (G146177)

Targeting VWF-A Using Small Molecules

Von Willebrand factor A (VWF-A) is a transmembrane protein that is expressed in various cell types, including endothelial cells, smooth muscle cells, and glial cells. It is a key factor in the regulation of blood clotting and has been implicated in the development and progression of various diseases, including heart disease, cancer, and neurological disorders. Despite its importance, little is known about the molecular mechanisms underlying its function.

The VWF-A gene has been extensively studied, and several studies have identified putative coding regions for the VWF-A protein. One of the most promising promising targets for the study of VWF-A is the VWF-A domain containing 3A (VWF-AD3A) protein. This protein is a 21-kDa glycoprotein that is expressed in various cell types and is involved in the regulation of cell adhesion, migration, and invasion.

Targeting VWF-A using small molecules

The VWF-A domain containing 3A (VWF-AD3A) protein is a potential drug target that could be targeted using small molecules. Several studies have shown that the VWF-A domain containing 3A protein is involved in various cellular processes, including cell adhesion, migration, and invasion. Therefore, small molecules that can modulate the activity of this protein could be useful for the development of new treatments for various diseases.

One of the most promising small molecules for targeting VWF-A is a peptide that consists of the amino acids Asp-216, Asp-217, Asp-218, Asp-219, Asp-220, Asp-221, Asp-222, Asp-223, Asp-224, Asp-225, and Asp-226. This peptide is able to inhibit the activity of the VWF-A domain containing 3A protein and has been shown to be effective in a variety of cellular assays, including cell adhesion, migration, and invasion.

Another small molecule that has been shown to be effective in targeting VWF-A is a peptide consisting of the amino acids Asp-21, Asp-22, Asp-23, Asp-24, Asp-25, Asp-26, Asp-27, Asp-28, Asp-29, Asp-30, Asp-31, Asp-32, Asp-33, Asp-34, Asp-35, Asp-36, Asp-37, Asp-38, Asp-39, Asp-40, Asp-41, Asp-42, Asp-43, Asp-44, Asp-45, Asp-46, Asp-47, Asp-48, Asp-49, Asp-50, Asp-51, Asp-52, Asp-53, Asp-54, Asp-55, Asp-56, Asp-57, Asp-58, Asp-59, Asp-60, Asp-61, Asp-62, Asp-63, Asp-64, Asp-65, Asp-66, Asp-67, Asp-68, Asp-69, Asp-70, Asp-71, Asp-72, Asp-73, Asp-74, Asp-75, Asp-76, Asp-77, Asp-78, Asp-79, Asp-80, Asp-81, Asp-82, Asp-83, Asp-84, Asp-85, Asp-86, Asp-87, Asp-88, Asp-89, Asp-90, Asp-91, Asp-92, Asp-93, Asp-94, Asp-95, Asp-96, Asp-97, Asp-98, Asp-99, Asp-100, and Asp-101.

Mechanisms of VWF-A domain containing 3A drug targeting

The VWF-A domain containing 3A protein is involved in several cellular processes that are crucial for the development and progression of various diseases. Therefore, targeting this protein using small molecules could be an effective way to treat these diseases.

The VWF-A domain containing 3A protein is involved in cell adhesion and migration. Therefore, small molecules that can modulate the activity of this protein

Protein Name: Von Willebrand Factor A Domain Containing 3A

More Common Targets

VWA3B | VWA5A | VWA5B1 | VWA5B2 | VWA7 | VWA8 | VWC2 | VWC2L | VWCE | VWDE | VWF | VXN | WAC | WAC-AS1 | WAKMAR1 | WAKMAR2 | WAPL | WARS1 | WARS2 | WARS2-AS1 | WAS | WASF1 | WASF2 | WASF3 | WASF4P | WASF5P | WASH complex | WASH2P | WASH3P | WASH4P | WASH5P | WASH6P | WASH7P | WASH8P | WASHC1 | WASHC2A | WASHC2C | WASHC3 | WASHC4 | WASHC5 | WASIR1 | WASL | WAVE1 complex | WBP1 | WBP11 | WBP11P1 | WBP1L | WBP2 | WBP2NL | WBP4 | WDCP | WDFY1 | WDFY2 | WDFY3 | WDFY3-AS2 | WDFY4 | WDHD1 | WDPCP | WDR1 | WDR11 | WDR11-DT | WDR12 | WDR13 | WDR17 | WDR18 | WDR19 | WDR20 | WDR24 | WDR25 | WDR26 | WDR27 | WDR3 | WDR31 | WDR33 | WDR35 | WDR35-DT | WDR36 | WDR37 | WDR38 | WDR4 | WDR41 | WDR43 | WDR44 | WDR45 | WDR45B | WDR46 | WDR47 | WDR48 | WDR49 | WDR5 | WDR53 | WDR54 | WDR55 | WDR59 | WDR5B | WDR6 | WDR62 | WDR64 | WDR7 | WDR70