Target Name: WARS2
NCBI ID: G10352
Other Name(s): tryptophan tRNA ligase 2, mitochondrial | Tryptophanyl tRNA synthetase 2, mitochondrial, transcript variant 2 | mtTrpRS | Tryptophan--tRNA ligase, mitochondrial precursor | Tryptophanyl-transfer RNA synthetase | L-tryptophan-tRNATrp ligase (AMP-forming) | SYWM_HUMAN | Tryptophanyl-transfer ribonucleic synthetase | Tryptophan--tRNA ligase, mitochondrial | PKDYS3 | Tryptophan tRNA ligase 2, mitochondrial | Tryptophan--tRNA ligase, mitochondrial (isoform 1) | TrpRS | NEMMLAS | Tryptophanyl-transfer ribonucleic acid synthetase | WARS2 variant 2 | Tryptophan--tRNA ligase, mitochondrial (isoform 2) | Tryptophanyl ribonucleic synthetase | Tryptophanyl tRNA synthetase 2, mitochondrial, transcript variant 1 | Tryptophanyl-tRNA synthetase, mitochondrial | Tryptophan translase | Tryptophanyl-tRNA synthetase | Tryptophanyl-transfer ribonucleate synthetase | WARS2 variant 1 | (Mt)TrpRS | tryptophanyl tRNA synthetase 2, mitochondrial | Tryptophan-tRNA ligase | Tryptophanyl-tRNA synthase

Wars2: A Potential Drug Target and Biomarker for Mitochondrial Function

Mitochondria are organelles responsible for generating energy in the form of ATP during the cell's metabolism. They are also involved in the production of various molecules, including proteins, lipids, and acids. One of the key proteins involved in these processes is Wars2, which is a tRNA ligase enzyme located in the mitochondria. Wars2 plays a crucial role in regulating the translation of mRNAs into the cytoplasm, which is the fluid surrounding the mitochondria.

The Importance of Wars2

Wars2 is a protein that is expressed in most tissues and cells of the body. It is a key component of the mitochondrial cytoskeleton and is involved in the regulation of various cellular processes, including protein synthesis, DNA replication, and metabolism. In addition, Wars2 is involved in the translation of mRNAs into the cytoplasm, which is a critical process for the production of proteins that are essential for cellular function.

Wars2 has been identified as a potential drug target due to its involvement in various cellular processes that are associated with various diseases, including cancer, neurodegenerative diseases, and cardiovascular diseases. In addition, Wars2 has been shown to be involved in the regulation of cellular processes that are related to aging, such as the regulation of DNA replication and the production of reactive oxygen species (ROS).

Drugs that Target Wars2

One of the primary goals of drug development is to identify small molecules that can inhibit the activity of Wars2 and prevent it from participating in cellular processes that are associated with various diseases. Currently, there are several drugs that are being developed as potential inhibitors of Wars2, including:

1. JNJ-752605: This is an inhibitor of Wars2 that is being developed by Johnson & Johnson for the treatment of neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease.
2. GSK-341203: This is an inhibitor of Wars2 that is being developed by GlaxoSmithKline (GSK) for the treatment of cancer.
3. IN-8012: This is an inhibitor of Wars2 that is being developed by InSightec for the treatment of inflammatory diseases, such as heart failure and diabetic foot ulcers.

Another approach to targeting Wars2 is to use small molecules that specifically interact with Wars2 and prevent it from participating in cellular processes. This approach is being used to develop drugs that target Wars2's activity in neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease.

Measurement of Wars2 Activity

Wars2 activity can be measured using various techniques, including:

1. Western blotting: This is a technique that can be used to measure the amount of Wars2 protein in a cell or tissue.
2. Immunofluorescence: This is a technique that can be used to visualize the localization of Wars2 in a cell or tissue.
3. Cell-based assays: This is a technique that involves culturing cells in a laboratory and measuring the activity of Wars2 using various cellular assays, such as cytoskeleton formation or protein synthesis.
4. In vitro assays: This is a technique that involves testing the activity of Wars2 in a laboratory setting using in vitro assays, such as the transcription assay or the translation assay.

Conclusion

Wars2 is a protein that is involved in various cellular processes that are critical for cellular function. It has been identified as a potential drug target due to its involvement in various diseases, including cancer, neurodegenerative diseases, and cardiovascular diseases. Currently, several drugs are being developed as potential inhibitors of Wars2, including JNJ-752605, GSK-341203, and IN-8012. In addition, small molecules that specifically interact with Wars2 are being developed as potential

Protein Name: Tryptophanyl TRNA Synthetase 2, Mitochondrial

Functions: Mitochondrial aminoacyl-tRNA synthetase that activate and transfer the amino acids to their corresponding tRNAs during the translation of mitochondrial genes and protein synthesis

More Common Targets

WARS2-AS1 | WAS | WASF1 | WASF2 | WASF3 | WASF4P | WASF5P | WASH complex | WASH2P | WASH3P | WASH4P | WASH5P | WASH6P | WASH7P | WASH8P | WASHC1 | WASHC2A | WASHC2C | WASHC3 | WASHC4 | WASHC5 | WASIR1 | WASL | WAVE1 complex | WBP1 | WBP11 | WBP11P1 | WBP1L | WBP2 | WBP2NL | WBP4 | WDCP | WDFY1 | WDFY2 | WDFY3 | WDFY3-AS2 | WDFY4 | WDHD1 | WDPCP | WDR1 | WDR11 | WDR11-DT | WDR12 | WDR13 | WDR17 | WDR18 | WDR19 | WDR20 | WDR24 | WDR25 | WDR26 | WDR27 | WDR3 | WDR31 | WDR33 | WDR35 | WDR35-DT | WDR36 | WDR37 | WDR38 | WDR4 | WDR41 | WDR43 | WDR44 | WDR45 | WDR45B | WDR46 | WDR47 | WDR48 | WDR49 | WDR5 | WDR53 | WDR54 | WDR55 | WDR59 | WDR5B | WDR6 | WDR62 | WDR64 | WDR7 | WDR70 | WDR72 | WDR73 | WDR74 | WDR75 | WDR76 | WDR77 | WDR81 | WDR82 | WDR82P1 | WDR83 | WDR83OS | WDR86 | WDR86-AS1 | WDR87 | WDR88 | WDR89 | WDR90 | WDR91 | WDR93