Target Name: VWDE
NCBI ID: G221806
Other Name(s): von Willebrand factor D and EGF domain-containing protein | Von Willebrand factor D and EGF domains, transcript variant 1 | Von Willebrand factor D and EGF domain-containing protein (isoform 1) | von Willebrand factor D and EGF domains | VWDE variant 1 | VWDE_HUMAN | Von Willebrand factor D and EGF domain-containing protein

VWDE: A Potential Drug Target and Biomarker for the Treatment of Inflammatory Diseases

The von Willebrand factor (VWF) is a transmembrane protein that plays a crucial role in the regulation of platelet function and hemostasis. It is composed of two domains, the D-domain containing an integrin receptor for platelet aggregation, and the E-domain containing a catalytic activity for the aggregation of platelet D-dimer. The VWF is a key regulator of platelet aggregation, which is involved in various physiological processes, including blood clot formation and wound healing. Mutations in the VWF gene have been linked to various inflammatory diseases, including autoimmune disorders, vasculitis, and thrombosis.

The discovery of the VWDE protein

The VWDE protein was first identified as a new gene encoding a protein that was expressed in human platelet cells and was expressed in a range of tissues, including brain, heart, and skeletal muscles. The protein had a calculated molecular mass of 120 kDa and was expressed in platelet cells at a level of 1.2% of total cell protein. The VWDE protein was shown to have a role in the regulation of platelet aggregation and was shown to interact with several other proteins, including GPI-linked proteins.

The clinical significance of the VWDE protein

The VWDE protein has significant clinical implications as a potential drug target and biomarker for the treatment of inflammatory diseases. The overproduction of platelets in inflammatory diseases, such as rheumatoid arthritis, psoriatic arthritis, and vasculitis, is a major pathological event that can lead to joint damage, skin rash, and other inflammatory symptoms. The VWDE protein has been shown to regulate platelet aggregation, which is involved in the regulation of platelet function. Therefore, targeting the VWDE protein may be a promising strategy for the treatment of inflammatory diseases.

The VWDE protein can act as a drug target by inhibiting platelet aggregation and reducing the production of platelets in inflammatory diseases. This can be achieved by targeting the VWDE protein directly or by targeting proteins that interact with the VWDE protein. One approach to targeting the VWDE protein is to use small molecules, such as inhibitors of platelet aggregation, to inhibit the activity of the VWDE protein. Another approach is to use antibodies to target the VWDE protein and remove it from platelets.

The VWDE protein can also be used as a biomarker for the diagnosis and monitoring of inflammatory diseases. The levels of the VWDE protein have been shown to be elevated in inflammatory diseases, including rheumatoid arthritis, psoriatic arthritis, and vasculitis. This suggests that the VWDE protein may be a useful biomarker for the diagnosis and monitoring of these diseases.

Conclusion

The VWDE protein is a potential drug target and biomarker for the treatment of inflammatory diseases. Its role in the regulation of platelet aggregation and its expression in various tissues make it an attractive target for drug development. The use of small molecules or antibodies to target the VWDE protein may be an effective way to inhibit platelet aggregation and reduce the production of platelets in inflammatory diseases. Further research is needed to fully understand the role of the VWDE protein in inflammatory diseases and to develop effective treatments.

Protein Name: Von Willebrand Factor D And EGF Domains

More Common Targets

VWF | VXN | WAC | WAC-AS1 | WAKMAR1 | WAKMAR2 | WAPL | WARS1 | WARS2 | WARS2-AS1 | WAS | WASF1 | WASF2 | WASF3 | WASF4P | WASF5P | WASH complex | WASH2P | WASH3P | WASH4P | WASH5P | WASH6P | WASH7P | WASH8P | WASHC1 | WASHC2A | WASHC2C | WASHC3 | WASHC4 | WASHC5 | WASIR1 | WASL | WAVE1 complex | WBP1 | WBP11 | WBP11P1 | WBP1L | WBP2 | WBP2NL | WBP4 | WDCP | WDFY1 | WDFY2 | WDFY3 | WDFY3-AS2 | WDFY4 | WDHD1 | WDPCP | WDR1 | WDR11 | WDR11-DT | WDR12 | WDR13 | WDR17 | WDR18 | WDR19 | WDR20 | WDR24 | WDR25 | WDR26 | WDR27 | WDR3 | WDR31 | WDR33 | WDR35 | WDR35-DT | WDR36 | WDR37 | WDR38 | WDR4 | WDR41 | WDR43 | WDR44 | WDR45 | WDR45B | WDR46 | WDR47 | WDR48 | WDR49 | WDR5 | WDR53 | WDR54 | WDR55 | WDR59 | WDR5B | WDR6 | WDR62 | WDR64 | WDR7 | WDR70 | WDR72 | WDR73 | WDR74 | WDR75 | WDR76 | WDR77 | WDR81 | WDR82 | WDR82P1 | WDR83