VPS4B: A Potential Drug Target for Neurological Disorders (G9525)

Target Name: VPS4B

NCBI ID: G9525

VPS4B: A Potential Drug Target for Neurological Disorders

VPS4B (vesicle-associated protein 4B) is a protein that is expressed in various cell types, including neurons, and is known to play a role in cell migration. It is a member of the voltage-dependent ion channel (VDF) family, which are involved in the regulation of ion traffic and neurotransmitter release.

Recent studies have suggested that VPS4B may be a drug target or biomarker for various neurological and psychiatric disorders, including Alzheimer's disease, Parkinson's disease, and schizophrenia. This is because the disruption of VPS4B has been observed to contribute to the pathophysiology of these disorders, and because the activation of VPS4B has been shown to promote the migration of neurons, which may be a potential therapeutic target.

In addition to its role in cell migration, VPS4B is also involved in the regulation of cell survival and stress resistance. It has been shown to play a role in the stress response, and to contribute to the regulation of cell apoptosis (programmed cell death) in response to stress.

The VPS4B protein is expressed in various tissues and cells, including the brain, and is involved in the regulation of a wide range of cellular processes, including neurotransmitter release, ion traffic, and cell survival. It is a member of the voltage-dependent Ion channel (VDF) family, and is expressed in a variety of tissues, including the brain, heart, and pancreas.

Recent studies have suggested that VPS4B may be a drug target or biomarker for a variety of neurological and psychiatric disorders, including Alzheimer's disease, Parkinson's disease, and schizophrenia. This is because the disruption of VPS4B has been observed to contribute to the pathophysiology of these disorders , and because the activation of VPS4B has been shown to promote the migration of neurons, which may be a potential therapeutic target.

In addition to its role in cell migration and stress response, VPS4B is also involved in the regulation of cell survival and stress resistance. It has been shown to play a role in the stress response, and to contribute to the regulation of cell apoptosis (programmed cell death) in response to stress.

VPS4B is a 120-kDa protein that is expressed in the brain and other tissues. It is a member of the voltage-dependent ion channel (VDF) family, and is involved in the regulation of a wide range of cellular processes, including neurotransmitter release, ion traffic, and cell survival.

In conclusion, VPS4B is a protein that is expressed in various tissues and cells, including the brain, and is involved in the regulation of a wide range of cellular processes. The disruption of VPS4B has been observed to contribute to the pathophysiology of various neurological and psychiatric disorders, and because the activation of VPS4B has been shown to promote the migration of neurons, it may be a potential therapeutic target. Further research is needed to fully understand the role of VPS4B in these disorders, and to determine the most effective method for its treatment.

Protein Name: Vacuolar Protein Sorting 4 Homolog B

Functions: Involved in late steps of the endosomal multivesicular bodies (MVB) pathway. Recognizes membrane-associated ESCRT-III assemblies and catalyzes their ATP-dependent disassembly, possibly in combination with membrane fission (PubMed:18687924). Redistributes the ESCRT-III components to the cytoplasm for further rounds of MVB sorting. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. VPS4A/B are required for the exosomal release of SDCBP, CD63 and syndecan (PubMed:22660413)

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