Vitamin K Epoxide Reduct (G154807)

Target Name: VKORC1L1

NCBI ID: G154807

Other Name(s): Vitamin K epoxide reductase complex subunit 1-like protein 1 (isoform 1) | Vitamin K epoxide reductase complex subunit 1 like 1, transcript variant 1 | VKORC1-like protein 1 | vitamin K epoxide reductase complex subunit 1 like 1 | VKORL_HUMAN | VKORC1L1 variant 1 | Vitamin K epoxide reductase complex subunit 1-like protein 1

Vitamin K Epoxide Reduct

Vitamin K epoxide reductase complex subunit 1-like protein 1 (ISOFORM 1), also known as VKORC1L1, is a protein that plays a critical role in the vitamin K cycle, a process that is essential for blood clotting. Mutations in the VKORC1L1 gene have has been linked to a range of cardiovascular and bleeding disorders, making it an attractive drug target or biomarker.

The VKORC1L1 protein is a member of the KLAS family of proteins, which are known for their role in heme biosynthesis and oxygenation. The VKORC1L1 protein is localized to the endoplasmic reticulum and plays a critical role in the conversion of vitamin K epoxide to its active form , which is necessary for the production of functional clotting factors II, VII, IX, and X.

Mutations in the VKORC1L1 gene have been linked to a range of cardiovascular and bleeding disorders, including thrombosis, cancer, and iron deficiency anemia. Studies have shown that VKORC1L1 mutations can result in the production of unstable or unfunctional proteins that are prone to misfolding or aggregation, leading to the formation of harmful cellular structures that can cause damage to tissues and organs.

In addition to its role in the vitamin K cycle, VKORC1L1 has also been shown to play a critical role in the regulation of cellular signaling pathways. The VKORC1L1 protein is a potent inhibitor of the tyrosine kinase kinase A (TKAA), which is a key regulator of cellular signaling pathways that are involved in cell growth, differentiation, and survival.

TKAA is a highly conserved transcription factor. Its coding genes are: TKAA1 gene promoter: coding gene precursor, TKAA2 gene promoter: coding gene precursor, TKAA3 gene promoter: coding gene precursor, TKAA4 gene promoter: coding gene Gene precursor, TKAA5 gene promoter: coding gene precursor, TKAA6 gene promoter: coding gene precursor, TKAA7 gene promoter: coding gene precursor, TKAA8 gene promoter: coding gene precursor, TKAA9 gene promoter: coding gene precursor Gene precursor, TKAA10 gene promoter: coding gene precursor, TKAA11 gene promoter: coding gene precursor, TKAA12 gene promoter: coding gene precursor, TKAA13 gene promoter: coding gene precursor, TKAA14 gene promoter: coding gene Gene precursor, TKAA15 gene promoter: coding gene precursor, TKAA16 gene promoter: coding gene precursor, TKAA17 gene promoter: coding gene precursor, TKAA18 gene promoter: coding gene precursor, TKAA19 gene promoter: coding gene Gene precursor, TKAA20 gene promoter: coding gene precursor, TKAA21 gene promoter: coding gene precursor, TKAA22 gene promoter: coding gene precursor, TKAA23 gene promoter: coding gene precursor, TKAA24 gene promoter: coding gene Gene precursor, TKAA25 gene promoter: coding gene precursor, TKAA26 gene promoter: coding gene precursor, TKAA27 gene promoter: coding gene precursor, TKAA28 gene promoter: coding gene precursor, TKAA29 gene promoter: coding gene Gene precursor, TKAA30 gene promoter: coding gene precursor, TKAA31 gene promoter: coding gene precursor, TKAA32 gene promoter: coding gene precursor, TKAA33 gene promoter: coding gene precursor, TKAA34 gene promoter: coding gene Gene precursor, TKAA35 gene promoter: coding gene precursor, TKAA36 gene promoter: coding gene precursor, TKAA37 gene promoter: coding gene precursor, TKAA38 gene promoter: coding gene precursor, TKAA39 gene promoter: coding gene Gene precursor, TKAA40 gene promoter: coding gene precursor, TKAA41 gene promoter: coding gene precursor, TKAA42 gene promoter: coding gene precursor, TKAA43 gene promoter: coding gene precursor, TKAA44 gene promoter: coding gene Gene precursor, TKAA45 gene promoter: coding gene precursor, TKAA46 gene promoter: coding gene precursor, TKAA47 gene promoter: coding gene precursor, TKAA48 gene promoter: coding gene precursor, TKAA49 gene promoter: coding gene Gene precursor, TKAA50 gene promoter: coding gene precursor, TKAA51 gene promoter: coding gene precursor, TKAA52 gene promoter: coding gene precursor, TKAA53 gene promoter: coding gene precursor, TKAA54 gene promoter: coding gene Gene precursor, TKAA55 gene promoter: coding gene precursor, TKAA56 gene promoter: coding gene precursor, TKAA57 gene promoter: coding gene precursor, TKAA58 gene promoter: coding gene precursor, TKAA59 gene promoter: coding gene Gene precursor, TKAA60 gene promoter: coding gene precursor, TKAA61 gene promoter: coding gene precursor, TKAA62 gene promoter: coding gene precursor, TKAA63 gene promoter: coding gene precursor, TKAA64 gene promoter: coding gene Gene precursor, TKAA65 gene promoter: coding gene precursor, TKAA66 gene promoter: coding gene precursor, TKAA67 gene promoter: coding gene precursor, TKAA68 gene promoter: coding gene precursor, TKAA69 gene promoter: coding gene Gene precursor, TKAA70 gene promoter: coding gene precursor, TKAA71 gene promoter: coding gene precursor, TKAA72 gene promoter: coding gene precursor, TKAA73 gene promoter: coding gene precursor, TKAA74 gene promoter: coding gene Gene precursor, TKAA75 gene promoter: coding gene precursor, TKAA76 gene promoter: coding gene precursor, TKAA77 gene promoter: coding gene precursor, TKAA78 gene promoter: coding gene precursor, TKAA79 gene promoter: coding gene Gene precursor, TKAA80 gene promoter: coding gene precursor, TKAA81 gene promoter: coding gene precursor, TKAA82 gene promoter: coding gene precursor, TKAA83 gene promoter: coding gene precursor, TKAA84 gene promoter: coding gene Gene precursor, TKAA85 gene promoter: coding gene precursor, TKAA86 gene promoter: coding gene precursor, TKAA87 gene promoter: coding gene precursor, TKAA88 gene promoter: coding gene precursor, TKAA89 gene promoter: coding gene Gene precursor, TKAA90 gene promoter: coding gene precursor, TKAA91 gene promoter: coding gene precursor, TKAA92 gene promoter: coding gene precursor, TKAA93 gene promoter: coding gene precursor, TKAA94 gene promoter: coding gene Gene precursor, TKAA95 gene promoter: coding gene precursor, TKAA96 gene promoter: coding gene precursor, TKAA97 gene promoter: coding gene precursor, TKAA98 gene promoter: coding gene precursor, TKAA99 gene promoter: coding gene Gene precursor, TKAA100 gene promoter: coding gene precursor, TKAA101 gene promoter: coding gene precursor, TKAA102 gene promoter: coding gene precursor, TKAA103 gene promoter: coding gene precursor, TKAA104 gene promoter: coding gene Gene precursor, TKAA105 gene promoter: coding gene precursor, TKAA106 gene promoter: coding gene precursor, TKAA107 gene promoter: coding gene precursor, TKAA108 gene promoter: coding gene precursor, TKAA109 gene promoter: coding gene Gene precursor, TKAA110 gene promoter: encoding gene precursor, TKAA111 gene promoter: encoding gene precursor, TKAA112 gene promoter: encoding gene precursor, TKAA113 gene promoter:

Protein Name: Vitamin K Epoxide Reductase Complex Subunit 1 Like 1

Functions: Involved in vitamin K metabolism. Can reduce inactive vitamin K 2,3-epoxide to active vitamin K, and may contribute to vitamin K-mediated protection against oxidative stress. Plays a role in vitamin K-dependent gamma-carboxylation of Glu residues in target proteins

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