VDAC3: A Potential Drug Target and Biomarker (G7419)

Target Name: VDAC3

NCBI ID: G7419

VDAC3: A Potential Drug Target and Biomarker

VDAC3 (Vitamin D-Active-Citrate synthase 3) is a protein that is expressed in various tissues and cells in the body. It is a key enzyme in the vitamin D synthesis pathway and is involved in the production of vitamin D from dietary sources such as sunlight, food, and supplements. VDAC3 has been identified as a potential drug target and biomarker for various diseases, including cancer, cardiovascular disease, and neurological disorders.

Overview of VDAC3

VDAC3 is a single-chain protein that contains 215 amino acid residues. It has a calculated molecular mass of 30,412 Daltons and a calculated pI of 10.5. VDAC3 is expressed in various tissues and cells, including the liver, muscle, heart, kidney, and intestine. It is also expressed in various cell types, including epithelial cells, endothelial cells, and immune cells. VDAC3 is involved in the production of vitamin D3 from its precursor, 25-hydroxyvitamin D3 (25-OH-D3).

In cancer, VDAC3 has been shown to be involved in various cellular processes that promote tumor growth and progression. For example, VDAC3 has been shown to be involved in the regulation of cell adhesion, migration, and invasion. It has also been shown to play a role in the production of pro-inflammatory cytokines, which can contribute to tumor immune evasion.

VDAC3 as a Drug Target

VDAC3 has been identified as a potential drug target for various diseases due to its involvement in various cellular processes that are associated with disease. For example, VDAC3 has been shown to be involved in the regulation of cell adhesion and migration, which are processes that are often disrupted in cancer cells. Therefore, compounds that can inhibit VDAC3 activity may be effective in treating various cancers, including breast, ovarian, and prostate cancers.

VDAC3 has also been shown to be involved in the production of pro-inflammatory cytokines, which can contribute to tumor immune evasion. Therefore, compounds that can inhibit VDAC3 activity may also be effective in treating various types of cancer that are resistant to conventional therapies.

VDAC3 as a Biomarker

VDAC3 has also been identified as a potential biomarker for various diseases due to its expression in various tissues and cells. Therefore, compounds that can be used to block VDAC3 activity may be useful in the diagnosis and prognosis of various diseases. For example, compounds that can inhibit VDAC3 activity may be used to treat diseases that are characterized by the production of pro-inflammatory cytokines, such as cancer, cardiovascular disease, and neurological disorders.

Conclusion

VDAC3 is a protein that is involved in the production of vitamin D from dietary sources. It has also been shown to be involved in various cellular processes that are associated with disease, including cancer and cardiovascular disease. Therefore, compounds that can inhibit VDAC3 activity may be effective in treating various diseases, including cancer, cardiovascular disease, and neurological disorders. Further research is needed to fully understand the role of VDAC3 as a drug target and biomarker.

Protein Name: Voltage Dependent Anion Channel 3

Functions: Forms a channel through the mitochondrial outer membrane that allows diffusion of small hydrophilic molecules (By similarity). Involved in male fertility and sperm mitochondrial sheath formation (By similarity)

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