Target Name: USP42
NCBI ID: G84132
Other Name(s): Ubiquitin thioesterase 42 | FLJ12697 | Deubiquitinating enzyme 42 | Ubiquitin specific protease 42 | Ubiquitin carboxyl-terminal hydrolase 42 (isoform 2) | ubiquitin thiolesterase 42 | ubiquitin-specific-processing protease 42 | Ubiquitin specific peptidase 42, transcript variant 2 | deubiquitinating enzyme 42 | UBP42_HUMAN | Ubiquitin carboxyl-terminal hydrolase 42 | ubiquitin specific peptidase 42 | ubiquitin specific protease 42 | ubiquitin thioesterase 42 | USP42 variant 2 | Ubiquitin thiolesterase 42 | Ubiquitin-specific-processing protease 42

USP42: A Potential Drug Target and Biomarker

USP42, or Ubiquitin thioesterase 42, is a protein that plays a critical role in the regulation of protein stability and quality control in cells. It is a member of the ubiquitin family, which is known for its role in regulating protein degradation and turnover. USP42 is a 42-kDa protein that is expressed in most tissues and cells in the body.

In recent years, USP42 has emerged as a potential drug target due to its involvement in a variety of cellular processes that are associated with aging and a variety of diseases, including cancer, neurodegenerative diseases, and autoimmune disorders. USP42 has also been shown to be involved in the regulation of inflammation and has been linked to the production of pro-inflammatory cytokines.

One of the key challenges in studying USP42 is its complex function and its interactions with other proteins. USP42 is a protein that is highly conserved across different species, which makes it difficult to study its function in isolation. However, researchers have been able to study its activity in various cellular processes by using a variety of techniques, including biochemical, cellular, and mass spectrometry-based assays.

One of the ways that researchers have studied USP42 is by using mass spectrometry to identify its protein sequence and to determine its three-dimensional structure. By these studies, researchers have been able to gain insight into the molecular mechanisms that are involved in USP42's function.

In addition to its potential drug-targeting properties, USP42 has also been shown to be a potential biomarker for a variety of diseases. For example, USP42 has been shown to be involved in the regulation of protein stability and has been linked to the production of pro-inflammatory cytokines. These observations make USP42 a potential target for drugs that are aimed at reducing inflammation or promoting cellular stability.

Another promising aspect of USP42 is its role in the regulation of cellular processes that are associated with aging. USP42 has been shown to be involved in the regulation of protein homeostasis, which is the ability of cells to maintain the proper concentration of proteins in different cellular compartments. As cells age, the ability of cells to maintain homeostasis becomes increasingly impaired, which can lead to a variety of cellular changes that are associated with aging and age-related diseases.

In conclusion, USP42 is a protein that has the potential to be a drug target or biomarker for a variety of diseases. Its complex function and interactions with other proteins make it difficult to study, but its study has already led to a better understanding of its role in cellular processes. Further research is needed to fully understand its function and its potential as a drug or biomarker.

Protein Name: Ubiquitin Specific Peptidase 42

Functions: Deubiquitinating enzyme which may play an important role during spermatogenesis

More Common Targets

USP43 | USP44 | USP45 | USP46 | USP46-DT | USP47 | USP48 | USP49 | USP5 | USP50 | USP51 | USP53 | USP54 | USP6 | USP6NL | USP6NL intronic transcript 1 (non-protein coding), transcript variant 1 | USP7 | USP8 | USP8P1 | USP9X | USP9Y | USPL1 | UST | UTF1 | UTP11 | UTP14A | UTP14C | UTP15 | UTP18 | UTP20 | UTP23 | UTP25 | UTP3 | UTP4 | UTP6 | UTRN | UTS2 | UTS2B | UTS2R | UTY | UVRAG | UVSSA | UXS1 | UXT | UXT-AS1 | VAC14 | Vacuolar H+ ATPase | VAMP1 | VAMP2 | VAMP3 | VAMP4 | VAMP5 | VAMP7 | VAMP8 | VANGL1 | VANGL2 | VAPA | VAPB | VARS1 | VARS2 | Vascular endothelial growth factor receptor (VEGFR) | Vascular endothelial growth factors (VEGF) | VASH1 | VASH1-AS1 | VASH2 | VASN | Vasoactive intestinal polypeptide receptor (VIP-R) | Vasohibin | Vasopressin Receptor | Vasopressin V1 Receptor | VASP | VAT1 | VAT1L | VAV1 | VAV2 | VAV3 | VAV3-AS1 | VAX1 | VAX2 | VBP1 | VCAM1 | VCAN | VCL | VCP | VCPIP1 | VCPKMT | VCX | VCX2 | VCX3A | VCX3B | VCY | VCY1B | VDAC1 | VDAC1P2 | VDAC1P9 | VDAC2 | VDAC2P5 | VDAC3 | VDR | VEGFA