Target Name: NLRP8
NCBI ID: G126205
Other Name(s): nucleotide-binding oligomerization domain protein 16 | PYRIN and NACHT-containing protein 4 | NACHT, LRR and PYD domains-containing protein 8 | NALP8 | NLRP8 variant 1 | Nucleotide-binding oligomerization domain protein 16 | Nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domain containing 8 | NACHT, leucine rich repeat and PYD containing 8 | NLR family pyrin domain containing 8, transcript variant 1 | PAN4 | NOD16 | CLR19.2 | NACHT, LRR and PYD containing protein 8 | nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domain containing 8 | NALP8_HUMAN | NACHT, LRR and PYD domains-containing protein 8 (isoform 1) | NLR family pyrin domain containing 8

NLRP8: A Protein Targeted for Drug Development

The nucleotide-binding oligomerization domain (NBD) protein NLRP8 is a key regulator of inflammation and stress responses in cells. The discovery of NLRP8 as a drug target has generated a great deal of interest and research in the field of pharmacology. In this article, we will provide an overview of NLRP8, its function, and potential as a drug target.

Function and localization

NLRP8 is a protein that belongs to the family of NBD proteins. These proteins are characterized by a conserved domain that includes a nucleotide-binding oligomerization domain (NBD), a protein-coding domain, and a C-terminal hypervariable region (HVR). NLRP8 is a 21-kDa protein that is expressed in various tissues and cells, including liver, muscle, heart, and brain. NLRP8 functions as a negative regulator of the unfolded state of other proteins, which is crucial for the regulation of protein stability and function.

Potential as a drug target

The discovery of NLRP8 as a drug target has generated a great deal of interest because of its potential role in the regulation of inflammation and stress responses. NLRP8 has been shown to play a role in the regulation of various cellular processes, including cell signaling, DNA damage repair, and inflammation. In addition, NLRP8 has been shown to interact with a variety of molecules, including drugs such as rapamycin and curcumin, which have been shown to modulate its function.

Drugs that target NLRP8 have been shown to have a variety of therapeutic effects, including the inhibition of inflammation and the regulation of stress responses. For example, the anti-inflammatory drug rapamycin has been shown to inhibit the activity of NLRP8 and prevent the regulation of unfolded proteins. Similarly, the antioxidant curcumin has been shown to modulate NLRP8 function and protect against oxidative stress.

Clinical applications

The potential of NLRP8 as a drug target is currently being investigated in various clinical trials. For example, a Phase 1 trial is being conducted to evaluate the safety and efficacy of the drug rapamycin in the treatment of rheumatoid arthritis (RA). The trial is designed to determine the optimal dose and duration of rapamycin treatment for the treatment of RA and to evaluate its effects on disease activity and safety.

In addition, there is also a great deal of interest in the use of NLRP8 as a biomarker for the diagnosis and prognosis of various diseases, including cancer. The expression of NLRP8 has been shown to be elevated in various types of cancer, including breast, lung, and colorectal cancer, and may be a useful diagnostic or prognostic marker.

Conclusion

NLRP8 is a protein that has significant functions in the regulation of inflammation and stress responses in cells. Its potential as a drug target has generated a great deal of interest and research in the field of pharmacology. The inhibition of NLRP8 function has been shown to have a variety of therapeutic effects, including the inhibition of inflammation and the regulation of stress responses. While further research is needed to fully understand the functions of NLRP8 and its potential as a drug target, its potential as a biomarker for the diagnosis and prognosis of various diseases makes it an important area of study.

Protein Name: NLR Family Pyrin Domain Containing 8

Functions: Involved in inflammation

More Common Targets

NLRP9 | NLRP9P1 | NLRX1 | NMB | NMBR | NMD3 | NMDA receptor | NME1 | NME1-NME2 | NME2 | NME2P1 | NME3 | NME4 | NME5 | NME6 | NME7 | NME8 | NME9 | NMI | NMNAT1 | NMNAT2 | NMNAT3 | NMRAL1 | NMRAL2P | NMRK1 | NMRK2 | NMS | NMT1 | NMT2 | NMTRQ-TTG10-1 | NMTRQ-TTG12-1 | NMTRV-TAC1-1 | NMU | NMUR1 | NMUR2 | NNAT | NNMT | NNT | NNT-AS1 | NOA1 | NOB1 | NOBOX | NOC2L | NOC2LP2 | NOC3L | NOC4L | NOCT | NOD1 | NOD2 | NODAL | NOG | NOL10 | NOL11 | NOL12 | NOL3 | NOL4 | NOL4L | NOL4L-DT | NOL6 | NOL7 | NOL8 | NOL9 | NOLC1 | NOM1 | NOMO1 | NOMO2 | NOMO3 | Non-protein coding RNA 185 | NONO | NOP10 | NOP14 | NOP14-AS1 | NOP16 | NOP2 | NOP53 | NOP56 | Nop56p-associated pre-rRNA complex | NOP58 | NOP9 | NOPCHAP1 | NORAD | NOS1 | NOS1AP | NOS2 | NOS2P1 | NOS2P2 | NOS2P3 | NOS3 | NOSIP | NOSTRIN | Notch ligands | Notch receptor | Notch Transcriptional Activation Complex | NOTCH1 | NOTCH2 | NOTCH2NLA | NOTCH2NLC | NOTCH3 | NOTCH4 | NOTO