Understanding The Role of GRAMD2A in Cellular Signaling (G196996)

Target Name: GRAMD2A

NCBI ID: G196996

Understanding The Role of GRAMD2A in Cellular Signaling

Gram domain containing 2A (GRAMD2A) is a protein that is expressed in various tissues of the body, including the brain, heart, and gastrointestinal tract. It is a member of the GRAM family of proteins, which are known for their role in intracellular signaling. While the exact function of GRAMD2A is not yet fully understood, it is possible that it may be a drug target or biomarker.

History ofGRAMD2A

TheGRAM family of proteins was first identified in the 1990s as a group of cytoplasmic proteins that were involved in intracellular signaling. These proteins were named based on their structure, which consists of a domain that is similar to the protein gram (G), a type of small protein that is found in various cell types.

While the first studies on theGRAM family were primarily focused on the identification and characterization of new proteins, later studies have provided more detailed information about the functions of these proteins. One of the most well-studied proteins in theGRAM family is GRAMD2A, which is also known as CRM170.

Expression and Localization

GRAMD2A is expressed in a variety of tissues and organs, including the brain, heart, and gastrointestinal tract. It is highly expressed in the brain, where it is found in the postsynaptic density of neurons and glial cells. It is also expressed in the heart, where it is involved in the regulation of contractility and heart rate.

GRAMD2A is also expressed in the gastrointestinal tract, where it is involved in the regulation of peristalsis and the secretion of digestive enzymes. It is thought to be involved in the development and maintenance of healthy gut function.

Function and Potential Therapeutic Applications

The exact function of GRAMD2A is not yet fully understood, but it is possible that it plays a role in intracellular signaling. Several studies have suggested that GRAMD2A may be involved in the regulation of cell proliferation, differentiation, and survival.

One potential therapeutic application for GRAMD2A is as a drug target. By inhibiting the activity of GRAMD2A, it may be possible to treat a variety of conditions, including cancer, neurodegenerative diseases, and gastrointestinal disorders.

Another potential application of GRAMD2A is as a biomarker. TheGRAM family of proteins is known for their ability to interact with small molecules, such as drugs and toxins. By using drugs that specifically target GRAMD2A, it may be possible to monitor the effectiveness of these drugs in the treatment of various diseases.

Conclusion

GRAMD2A is a protein that is expressed in various tissues of the body and is thought to be involved in intracellular signaling. While the exact function of GRAMD2A is not yet fully understood, it is possible that it may be a drug target or biomarker. Further research is needed to fully determine the role of GRAMD2A in the regulation of cellular processes and to explore its potential therapeutic applications.

Protein Name: GRAM Domain Containing 2A

Functions: Participates in the organization of endoplasmic reticulum-plasma membrane contact sites (EPCS) with pleiotropic functions including STIM1 recruitment and calcium homeostasis. Constitutive tether that co-localize with ESYT2/3 tethers at endoplasmic reticulum-plasma membrane contact sites in a phosphatidylinositol lipid-dependent manner. Pre-marks the subset of phosphtidylinositol 4,5-biphosphate (PI(4,5)P2)-enriched EPCS destined for the store operated calcium entry pathway (SOCE)

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