GRB14: Potential Drug Target and Biomarker (G2888)

Target Name: GRB14

NCBI ID: G2888

GRB14: Potential Drug Target and Biomarker

GRB14 (G protein-coupled receptor 14) is a protein that is expressed in many different tissues throughout the body. It is a member of the G protein-coupled receptor family, which is a large superfamily of transmembrane proteins that play a key role in cellular signaling. GRB14 is one of the most well-studied G protein-coupled receptors, and a number of different studies have identified potential drug targets or biomarkers associated with its function.

GRB14 is involved in a wide range of physiological processes in the body, including sensory perception, neurotransmission, and hormone regulation. It is expressed in many different tissues, including the brain, eye, heart, kidneys, and gastrointestinal tract. It is also involved in many different signaling pathways, including the regulation of pain, inflammation, and blood pressure.

One of the most promising aspects of GRB14 is its potential as a drug target. Several studies have identified potential binding sites on GRB14 that could be targeted by small molecules. These binding sites are located in the extracellular region of the protein, and they are involved in the regulation of a wide range of cellular processes, including cell signaling, cell adhesion, and neurotransmission.

In addition to its potential as a drug target, GRB14 is also a potential biomarker for a number of different diseases. For example, several studies have suggested that changes in the levels of GRB14 expression may be associated with a range of diseases, including cancer, neurodegenerative diseases, and mood disorders. These changes in GRB14 expression may be due to the activity of the protein itself, or they may be due to the presence of GRB14 in the tissue of interest.

Overall, GRB14 is a well-studied protein that is involved in a wide range of physiological processes in the body. Its potential as a drug target or biomarker is an exciting area of research, and further studies are needed to fully understand its function and potential applications in medicine.

Protein Name: Growth Factor Receptor Bound Protein 14

Functions: Adapter protein which modulates coupling of cell surface receptor kinases with specific signaling pathways. Binds to, and suppresses signals from, the activated insulin receptor (INSR). Potent inhibitor of insulin-stimulated MAPK3 phosphorylation. Plays a critical role regulating PDPK1 membrane translocation in response to insulin stimulation and serves as an adapter protein to recruit PDPK1 to activated insulin receptor, thus promoting PKB/AKT1 phosphorylation and transduction of the insulin signal

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