Glutathione Synthetase: A Protein Involved in Various Cellular Processes

Target Name: GSS

NCBI ID: G2937

Glutathione Synthetase: A Protein Involved in Various Cellular Processes

Glutathione synthetase (GSS) is a protein that is involved in the production of the antioxidant glutathione. Glutathione is a naturally occurring protein that is synthesized by the liver and is responsible for protecting the body against oxidative stress. In addition to its role in maintaining cellular health, glutathione has also been shown to play a key role in the immune system and has been linked to a number of diseases, including cancer, neurodegenerative disorders, and autoimmune diseases.

GSS is a transcript variant of the gene that encodes the protein. There are several different transcript variants of the gene, each of which produces a different protein. GSS is one of the most well-studied of the GSS transcript variants, and several studies have investigated its role in various cellular and biological processes.

One of the key functions of GSS is its role in the production of glutathione. Glutathione is a naturally occurring antioxidant that is synthesized by the liver and is responsible for protecting the body against oxidative stress. Glutathione has been shown to play a key role in the immune system and is involved in a number of physiological processes that are critical for cellular health.

In addition to its role in the production of glutathione, GSS has also been shown to play a key role in the regulation of cellular processes that are important for the development and maintenance of tissues. For example, GSS has been shown to play a key role in the development and maintenance of the skin, and has been linked to a number of skin diseases, including eczema and psoriasis.

GSS has also been shown to play a key role in the regulation of the blood vessels and has been linked to a number of cardiovascular diseases. For example, GSS has been shown to play a key role in the regulation of blood vessel diameter and has been linked to the development of cardiovascular disease.

In addition to its role in the production and regulation of glutathione and other proteins, GSS has also been shown to play a key role in the development and maintenance of tissues and organs. For example, GSS has been shown to play a key role in the development and maintenance of the liver, and has been linked to a number of liver diseases, including cirrhosis and steatohepatitis.

GSS has also been shown to play a key role in the regulation of cellular processes that are important for the development and maintenance of the nervous system. For example, GSS has been shown to play a key role in the development and maintenance of the brain, and has been linked to a number of neurological diseases, including Alzheimer's disease and Parkinson's disease.

GSS has also been shown to play a key role in the regulation of cellular processes that are important for the development and maintenance of the immune system. For example, GSS has been shown to play a key role in the development and regulation of T cells, and has been linked to a number of immune system disorders, including autoimmune diseases.

In conclusion, GSS is a protein that has been shown to play a key role in a number of cellular and biological processes. Its role in the production and regulation of glutathione and other proteins, as well as its role in the development and maintenance of tissues and organs, make it an attractive target for drug development. Further research is needed to fully understand the role of GSS in various biological processes and to develop effective treatments for diseases that are associated with its dysfunction.

Protein Name: Glutathione Synthetase

Functions: Catalyzes the production of glutathione from gamma-glutamylcysteine and glycine in an ATP-dependent manner (PubMed:7646467, PubMed:9215686). Glutathione (gamma-glutamylcysteinylglycine, GSH) is the most abundant intracellular thiol in living aerobic cells and is required for numerous processes including the protection of cells against oxidative damage, amino acid transport, the detoxification of foreign compounds, the maintenance of protein sulfhydryl groups in a reduced state and acts as a cofactor for a number of enzymes (PubMed:10369661). Participates in ophthalmate biosynthesis in hepatocytes (By similarity)

More Common Targets