GTF3C5: A Potential Drug Target for Cancer and Neurological Disorders

Target Name: GTF3C5

NCBI ID: G9328

GTF3C5: A Potential Drug Target for Cancer and Neurological Disorders

Gene transcription factor IIIC (GTF3C5) is a protein that plays a crucial role in the regulation of gene expression in various organisms, including humans. GTF3C5 is a member of the GTF21 family, which is known to be involved in the regulation of cellular processes such as cell growth, differentiation, and metabolism.

GTF3C5 is expressed in various tissues and cells throughout the body, including the brain, heart, and gastrointestinal tract. It is highly expressed in the brain, where it is involved in the regulation of neuronal excitability and synaptic plasticity.

GTF3C5 is a transcriptional regulator that can bind to specific DNA sequences with high affinity. It has been shown to play a role in the regulation of various gene expression patterns, including the expression of genes involved in cell adhesion, migration, and survival.

GTF3C5 is also known to be involved in the regulation of cellular processes that are important for cancer progression. It has been shown to promote the growth and survival of various cancer cell types, including breast, ovarian, and colorectal cancer.

GTF3C5 is a potential drug target that could be targeted with small molecules or other therapeutic agents. There is ongoing research into the use of small molecules and other therapeutic agents to inhibit the activity of GTF3C5 and prevent its ability to promote cancer cell growth.

History of GTF3C5 Research

The study of GTF3C5 and its role in gene regulation has been ongoing for several years. Initial research studies identified GTF3C5 as a potential drug target due to its involvement in the regulation of cellular processes that are important for cancer progression.

GTF3C5 has been shown to promote the growth and survival of various cancer cell types, including breast, ovarian, and colorectal cancer. This suggests that GTF3C5 may be a useful target for cancer therapies that focus on inhibiting its activity.

Further research has shown that GTF3C5 is involved in the regulation of various gene expression patterns in the brain, where it is involved in the regulation of neuronal excitability and synaptic plasticity. This suggests that GTF3C5 may be involved in the development and progression of certain neurological disorders, such as Alzheimer's disease and Parkinson's disease.

GTF3C5 is also involved in the regulation of cellular processes that are important for cell adhesion, migration, and survival. These processes are important for the development and maintenance of tissues and organs, and may be involved in the development of various diseases, including cancer.

Molecular Mechanisms of GTF3C5

GTF3C5 is a transcriptional regulator that can bind to specific DNA sequences with high affinity. It has been shown to play a role in the regulation of various gene expression patterns, including the expression of genes involved in cell adhesion, migration, and survival.

GTF3C5 has a molecular structure that includes a N-terminus, a catalytic domain, and a C-terminus. The N-terminus of GTF3C5 contains a putative nuclear localization domain (NLD) that is involved in the regulation of gene expression.

The catalytic domain of GTF3C5 contains a multiple catalytic active site that is involved in the regulation of protein-protein interactions and the catalytic activity of GTF3C5. This domain is known as the TF-binding site and is the site of interaction between GTF3C5 and other proteins.

GTF3C5 also has a C-terminus that is involved in the regulation of gene expression. This region of GTF3C5 has been shown to be involved in the regulation of

Protein Name: General Transcription Factor IIIC Subunit 5

Functions: Involved in RNA polymerase III-mediated transcription. Integral, tightly associated component of the DNA-binding TFIIIC2 subcomplex that directly binds tRNA and virus-associated RNA promoters

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