GUSBP1: A Potential Drug Target and Biomarker (G728411)

GUSBP1: A Potential Drug Target and Biomarker

GUSBP1, also known as GUSB pseudogene 1, transcript variant 1, is a gene that encodes for a protein known as GUSB1. GUSB1 is a transmembrane protein that is involved in various cellular processes, including intracellular signaling, protein-protein interactions, and intracellular signaling pathways. GUSB1 has been shown to play a crucial role in the development and progression of various diseases, including cancer, neurodegenerative diseases, and autoimmune disorders.

GUSB1 functions as a negative regulator of the NF-kappa-B signaling pathway, which is a well-known pathway involved in various cellular processes, including inflammation, cell survival, and transcriptional regulation. The NF-kappa-B signaling pathway is activated in response to various stimuli, including stress, inflammation, and growth factors. Activation of the NF-kappa-B pathway can lead to the production of pro-inflammatory cytokines and the activation of various transcription factors, which can cause harm to the cell and contribute to the development of various diseases.

GUSB1 has been shown to play a negative role in the regulation of NF-kappa-B signaling pathway. GUSB1 has been shown to inhibit the NF-kappa-B pathway by preventing the phosphorylation of the nuclear factor kappa B (NF-kappa-B) at the activity site responsible for the NF-kappa-B signature protein p65. The phosphorylation of p65 is a critical event in the NF-kappa-B pathway, and the inhibition of GUSB1 has been shown to reduce the NF-kappa-B pathway activity.

GUSB1 has also been shown to play a role in the regulation of cell apoptosis, which is the process by which cells die naturally in response to various stimuli, including stress, nutrient deprivation, and DNA damage. GUSB1 has been shown to prevent the execution of the apoptosis program by inhibiting the cleavage of the caspase-34 protein by the procaspase-34 enzyme. The cleavage of caspase-34 by procaspase-34 is a critical event in the apoptosis program, and the inhibition of GUSB1 has been shown to increase the likelihood of cell survival.

GUSB1 has also been shown to play a role in the regulation of cellular signaling pathways, including the TGF-β pathway. The TGF-β pathway is involved in the regulation of cellular growth, cell differentiation, and inflammation. GUSB1 has been shown to regulate the TGF-β pathway by preventing the phosphorylation of the transforming growth factor beta 1 (TGF-β1) at the activity site responsible for the TGF-β1 signature protein Smad2. The phosphorylation of TGF-β1 by Smad2 is a critical event in the TGF-β pathway, and the inhibition of GUSB1 has been shown to reduce the TGF-β pathway activity.

In conclusion, GUSB1 is a gene that encodes for a protein involved in various cellular processes, including intracellular signaling, protein-protein interactions, and intracellular signaling pathways. GUSB1 has been shown to play a crucial role in the development and progression of various diseases, including cancer, neurodegenerative diseases, and autoimmune disorders. The inhibition of GUSB1 has been shown to increase the likelihood of cell survival and to reduce the NF-kappa-B and TGF-β pathway activities, which can contribute to the development of various diseases. Therefore, GUSB1 is a potential drug target and biomarker for various diseases.

Protein Name: GUSB Pseudogene 1

More Common Targets

GUSBP11 | GUSBP12 | GUSBP14 | GUSBP15 | GUSBP17 | GUSBP2 | GUSBP3 | GUSBP4 | GUSBP5 | GUSBP8 | GVINP1 | GVQW3 | GXYLT1 | GXYLT1P3 | GXYLT1P4 | GXYLT1P6 | GXYLT2 | GYG1 | GYG2 | GYPA | GYPB | GYPC | GYPE | GYS1 | GYS2 | GZF1 | GZMA | GZMB | GZMH | GZMK | GZMM | H1-0 | H1-1 | H1-10 | H1-10-AS1 | H1-2 | H1-3 | H1-4 | H1-5 | H1-6 | H1-7 | H1-8 | H1-9P | H19 | H19-ICR | H2AB1 | H2AB2 | H2AB3 | H2AC1 | H2AC11 | H2AC12 | H2AC13 | H2AC14 | H2AC15 | H2AC16 | H2AC17 | H2AC18 | H2AC20 | H2AC21 | H2AC25 | H2AC3P | H2AC4 | H2AC6 | H2AC7 | H2AJ | H2AP | H2AX | H2AZ1 | H2AZ1-DT | H2AZ2 | H2AZ2-DT | H2AZP2 | H2BC1 | H2BC10 | H2BC11 | H2BC12 | H2BC12L | H2BC13 | H2BC14 | H2BC15 | H2BC17 | H2BC18 | H2BC20P | H2BC21 | H2BC26 | H2BC27P | H2BC3 | H2BC4 | H2BC5 | H2BC6 | H2BC7 | H2BC8 | H2BC9 | H2BP1 | H2BP2 | H2BP3 | H2BW1 | H2BW2 | H2BW4P | H3-3A