Target Name: H2BC1
NCBI ID: G255626
Other Name(s): H2B histone family, member U, (testis-specific) | TSH2B.1 | H2BFU | TSH2B | histone cluster 1, H2ba | H2B1A_HUMAN | Histone H2B, testis | HIST1H2BA | testis-specific histone H2B | Histone H2B type 1-A | bA317E16.3 | TH2B | Testis-specific histone H2B | histone cluster 1 H2B family member a | Histone 1, H2ba | H2B clustered histone 1 | histone H2B, testis | hTSH2B | histone 1, H2ba | STBP

H2B1: A Key Regulator of Testicular Development and Function

The H2B histone family plays a crucial role in the regulation of various cellular processes in the body. One of the subfamilies, H2B1 (also known as H2BC1), is a key player in the regulation of testicular development and function. In fact, H2B1 is the only histone subfamily that is specifically expressed in the tests, making it an attractive drug target or biomarker in the field of goncology.

The H2B1 histone is a 20-kDa protein that is composed of two alpha helices and a beta sheet. It is one of the smallest histones, and its compact structure allows it to interact strongly with other proteins, including transcription factors that play a critical role in the regulation of gene expression.

H2B1 is expressed in a variety of tissues, including testes, where it is primarily involved in the regulation of fetal development and testicular function. In fact, H2B1 is critical for the normal development and function of the testes, as it helps to ensure the proper structure and organization of the spermatozoa.

One of the key functions of H2B1 is its role in the regulation of gene expression. It has been shown to interact with a wide range of transcription factors, including those that control the expression of genes involved in testicular development and function. For example, H2B1 has been shown to interact with the transcription factor, PDX-1, which is involved in the regulation of testicular growth and development.

Another key function of H2B1 is its role in the regulation of cellular signaling pathways. It has been shown to play a critical role in the regulation of the PI3K/Akt signaling pathway, which is involved in the regulation of various cellular processes, including cell growth , survival, and angiogenesis.

In addition to its role in the regulation of cellular processes, H2B1 is also a potential drug target. Its small size and the fact that it is expressed in only one tissue make it an attractive target for small molecule inhibitors. Several studies have shown that inhibitors of H2B1 have the potential to be effective in treating a variety of cancers, including testicular cancer.

One of the most promising compounds that has been shown to inhibit H2B1 is a small molecule called, 2-[(4-methoxybenzyl)amino]-2-methylphenyl-1-propanone (SM-3). SM-3 is a inhibitor of the protein kinase B, which is involved in the regulation of many cellular processes, including cell growth, survival, and angiogenesis.

SM-3 has been shown to be effective in treating a variety of cancers, including testicular cancer. In a series of studies, it has been shown to be effective in inhibiting the growth of cancer cells in a variety of models, including cell lines and animal models.

Another potential drug that may target H2B1 is a small molecule called, 2-[(4-methoxybenzyl)amino]-2-methylphenyl-1-propanone (SM-4). SM-4 is a similar compound to SM-3, but with a different chemical structure. Like SM-3, SM-4 has been shown to be effective in treating various cancers, including testicular cancer.

While the potential benefits of targeting H2B1 with small molecules are promising, it is important to note that further research is needed to fully understand its role in the regulation of testicular development and function. Additionally, the use of SM-3 and SM-4 as drugs against testicular cancer is still in the early stages of development and more studies are needed to confirm their safety and efficacy.

In conclusion, H2B1 is a key player in the regulation of testicular development and function, and its small size and the fact that it is expressed in only one tissue make it an attractive drug target or biomarker. The regulation of gene expression and cellular signaling pathways are

Protein Name: H2B Clustered Histone 1

Functions: Variant histone specifically required to direct the transformation of dissociating nucleosomes to protamine in male germ cells (By similarity). Entirely replaces classical histone H2B prior nucleosome to protamine transition and probably acts as a nucleosome dissociating factor that creates a more dynamic chromatin, facilitating the large-scale exchange of histones (By similarity). Core component of nucleosome (By similarity). Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template (By similarity). Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability (By similarity). DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling (By similarity). Also found in fat cells, its function and the presence of post-translational modifications specific to such cells are still unclear (PubMed:21249133)

More Common Targets

H2BC10 | H2BC11 | H2BC12 | H2BC12L | H2BC13 | H2BC14 | H2BC15 | H2BC17 | H2BC18 | H2BC20P | H2BC21 | H2BC26 | H2BC27P | H2BC3 | H2BC4 | H2BC5 | H2BC6 | H2BC7 | H2BC8 | H2BC9 | H2BP1 | H2BP2 | H2BP3 | H2BW1 | H2BW2 | H2BW4P | H3-3A | H3-3B | H3-4 | H3-5 | H3-7 | H3C1 | H3C10 | H3C11 | H3C12 | H3C13 | H3C14 | H3C15 | H3C2 | H3C3 | H3C4 | H3C6 | H3C7 | H3C8 | H3P16 | H3P36 | H3P37 | H3P44 | H3P5 | H3P6 | H4C1 | H4C11 | H4C12 | H4C13 | H4C14 | H4C15 | H4C16 | H4C2 | H4C3 | H4C4 | H4C5 | H4C6 | H4C7 | H4C8 | H4C9 | H6PD | HAAO | HABP2 | HABP4 | HACD1 | HACD2 | HACD3 | HACD4 | HACE1 | HACL1 | HADH | HADHA | HADHAP1 | HADHB | HAFML | HAGH | HAGHL | HAGLR | HAGLROS | HAL | HAMP | HAND1 | HAND2 | HAND2-AS1 | HAO1 | HAO2 | HAO2-IT1 | HAP1 | HAPLN1 | HAPLN2 | HAPLN3 | HAPLN4 | HAPSTR1 | HAR1A | HAR1B