Hepcidin Antimicrobial Peptide: A Promising Drug Target Or Biomarker

Target Name: HAMP

NCBI ID: G57817

Hepcidin Antimicrobial Peptide: A Promising Drug Target Or Biomarker

Hepcidin antimicrobial peptide (HAMP) is a naturally occurring peptide that is found in human blood plasma. It is composed of 134 amino acids and has been shown to have antimicrobial properties. HAMP has been identified as a potential drug target and a biomarker for various diseases, including diabetes, cancer, and respiratory tract infections.

HAMP has been shown to have anti-inflammatory effects, which can be beneficial for reducing the risk of chronic diseases. It has also been shown to have anti-cancer effects, by inhibiting the growth of cancer cells. In addition, HAMP has been shown to have anti-diabetic effects, by regulating the production of insulin by the pancreas.

HAMP has also been shown to have respiratory tract infection-preventing effects, by blocking the activity of bacteria that cause respiratory tract infections. This makes it a potential treatment for respiratory tract infections, such as pneumonia and bronchitis.

In addition to its potential therapeutic uses, HAMP has also been shown to have potential diagnostic uses. The levels of HAMP have been shown to be decreased in individuals with certain diseases, such as diabetes and cancer. This suggests that HAMP may be a useful biomarker for these diseases. In addition, HAMP has been shown to have a negative impact on the growth of cancer cells, which could make it a useful target for cancer treatments.

Overall, HAMP is a promising compound that has the potential to be a drug target or biomarker for a variety of diseases. Further research is needed to fully understand its therapeutic and diagnostic uses.

Protein Name: Hepcidin Antimicrobial Peptide

Functions: Liver-produced hormone that constitutes the main circulating regulator of iron absorption and distribution across tissues. Acts by promoting endocytosis and degradation of ferroportin/SLC40A1, leading to the retention of iron in iron-exporting cells and decreased flow of iron into plasma (PubMed:22682227, PubMed:29237594, PubMed:32814342). Controls the major flows of iron into plasma: absorption of dietary iron in the intestine, recycling of iron by macrophages, which phagocytose old erythrocytes and other cells, and mobilization of stored iron from hepatocytes (PubMed:22306005)

More Common Targets