HAS2: A Drug Target / Disease Biomarker (G3037)

Target Name: HAS2

NCBI ID: G3037

HAS2: A Drug Target / Disease Biomarker

HAS2, also known as heat-adapted simpleucin (HAS), is a protein that is expressed in various tissues of the body, including the skin, hair, and nails. It is a member of the heat-adapted protein (HAP) family, which are known to play a crucial role in the regulation of cellular processes that are temperature-dependent.

One of the unique features of HAS2 is its ability to undergo a conformational change in response to heat, which allows it to participate in various physiological processes that require temperature regulation. This conformational change involves the formation of a distinct dimer structure, which has been shown to alter the protein's stability and localization in the cell.

HAS2 has been shown to play a key role in the regulation of cell proliferation, differentiation, and survival. In fact, HAS2 has been shown to be involved in the development and maintenance of various diseases, including cancer, neurodegenerative diseases, and autoimmune disorders.

One of the key reasons for the interest in HAS2 is its potential as a drug target or biomarker. The conformational changes that occur in response to heat have been shown to be sensitive to various therapeutic interventions, which may make HAS2 an attractive target for small molecules. Additionally, the role of HAS2 in various physiological processes makes it a potential biomarker for various diseases.

In addition to its potential as a drug target or biomarker, HAS2 is also of interest due to its potential role in the development of personalized medicine. The regulation of cellular processes by HAPs is a key factor in the development of cancer, and personalized medicine strategies are being developed to tailor treatments to individual patients based on their unique genetic and environmental backgrounds. Since HAS2 is involved in the regulation of cellular processes that are temperature-dependent, it may be a useful target for personalized medicine strategies.

In conclusion, HAS2 is a protein that has been shown to play a crucial role in the regulation of various physiological processes in the body. Its ability to undergo conformational changes in response to heat makes it an attractive target for small molecules and personalized medicine strategies. Further research is needed to fully understand the role of HAS2 in the regulation of cellular processes and its potential as a drug target or biomarker.

Protein Name: Hyaluronan Synthase 2

Functions: Catalyzes the addition of GlcNAc or GlcUA monosaccharides to the nascent hyaluronan polymer (PubMed:20507985, PubMed:32993960, PubMed:23303191, PubMed:21228273) (Probable). Therefore, it is essential to hyaluronan synthesis a major component of most extracellular matrices that has a structural role in tissues architectures and regulates cell adhesion, migration and differentiation (PubMed:8798477, PubMed:21228273, PubMed:20507985). This is one of three isoenzymes responsible for cellular hyaluronan synthesis and it is particularly responsible for the synthesis of high molecular mass hyaluronan (By similarity)

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