H3K44: A Promising Drug Target and Biomarker (G347376)

Target Name: H3P44

NCBI ID: G347376

Other Name(s): H3 histone, family 3A, pseudogene 5 | H3F3AP5 | P55 | H3.8 | p55 | H3 histone pseudogene 44

H3K44: A Promising Drug Target and Biomarker

Histone modifications play a critical role in the regulation of gene expression and are involved in various cellular processes. One of the histone modifications is H3K44, also known as H3P44, which is a type of histone modification that is often targeted by drugs.

H3K44 is a pseudogene that is located on chromosome 18q21. It is a 25-kDa protein that is composed of two histone domains, H3K4 and H3K36. H3K44 is primarily targeted by drugs that inhibit the activity of the enzyme HDACs (histone-modifying enzymes), which are responsible for modifying the histone structure.

The H3K44 pseudogene is a promising drug target because it is involved in various cellular processes, including cell growth, differentiation, and response to stimuli. It is also involved in the regulation of cell-cell adhesion, which is critical for the maintenance of tissue structure and function.

One of the main advantages of H3K44 as a drug target is its expression in various tissues and cells. H3K44 is expressed in most tissues of the body, including brain, muscle, heart, and blood cells. It is also expressed in various cell types, including neurons, astrocytes, and cancer cells. This makes it an attractive target for drugs that can modulate its expression and activity.

Another advantage of H3K44 is its role in the regulation of cellular processes. H3K44 is involved in the regulation of cell growth, cell cycle progression, and apoptosis. It is also involved in the regulation of cell-cell adhesion and in the regulation of various signaling pathways, including the TGF-β pathway.

In addition to its role in cellular processes, H3K44 is also a potential biomarker for various diseases. For example, it has been shown to be involved in the regulation of cancer cell growth and has been used as a biomarker for various types of cancer, including breast, ovarian, and colorectal cancers.

The identification of H3K44 as a potential drug target and biomarker has led to a significant increase in the number of studies that have investigated its role in various cellular processes and diseases. These studies have provided valuable insights into the molecular mechanisms underlying the regulation of H3K44 and have identified potential drug targets and biomarkers for this protein.

In conclusion, H3K44 is a pseudogene that is expressed in most tissues of the body and is involved in various cellular processes. Its potential as a drug target and biomarker has led to a significant increase in the number of studies that have investigated its role in various diseases. Further research is needed to fully understand the molecular mechanisms underlying the regulation of H3K44 and to identify potential drug targets and biomarkers for this protein.

Protein Name: H3 Histone Pseudogene 44

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