HADHB: A Drug Target / Disease Biomarker (G3032)

Target Name: HADHB

NCBI ID: G3032

Other Name(s): 2-enoyl-Coenzyme A (CoA) hydratase, beta subunit | hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), beta subunit | ECHB_HUMAN | MTPB | MGC87480 | Mitochondrial trifunctional protein, beta subunit | HADHB variant 1 | 3-ketoacyl-CoA thiolase | TP-beta | Hydroxyacyl-Coenzyme A (CoA) dehydrogenase, beta subunit | acetyl-CoA acyltransferase | Trifunctional enzyme subunit beta, mitochondrial | beta-ketothiolase | hydroxyacyl-Coenzyme A dehydrogenase/3-ketoacyl-Coenzyme A thiolase/enoyl-Coenzyme A hydratase (trifunctional protein), beta subunit | Hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit beta, transcript variant 1 | TP-BETA | Acetyl-CoA acyltransferase | ECHB | Trifunctional enzyme subunit beta, mitochondrial isoform 1 precursor (isoform 1) | Mitochondrial trifunctional enzyme, beta subunit | hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit beta | 3-ketoacyl-Coenzyme A (CoA) thiolase of mitochondrial trifunctional protein, beta subunit | MSTP029

HADHB: A Drug Target / Disease Biomarker

HADHB, or hypoxic-adaptive domain-containing protein, is a protein that is expressed in various tissues throughout the body. It is a key regulator of cellular processes that are critical for the survival and proper functioning of tissues. HADHB has been identified as a potential drug target and has been shown to play a role in a variety of diseases, including cancer, neurodegenerative diseases, and respiratory disorders.

HADHB is a protein that is composed of two domains: an N-terminal hypoxic domain and a C-terminal adaptable domain. The N-terminal domain is responsible for the protein's ability to regulate oxygen availability in cells and is critical for its function as a regulator of cellular processes that are related to oxygenation. The C-terminal domain is responsible for the protein's ability to adapt to different cellular environments and is critical for its function as a regulator of cellular processes that are related to cell survival.

HADHB is expressed in a variety of tissues throughout the body, including the brain, heart, lungs, and kidneys. It is also expressed in various cell types, including neurons, astrocytes, and epithelial cells. HADHB plays a role in the regulation of cellular processes that are critical for the survival and proper functioning of these tissues, including the regulation of oxygenation, cell growth, and cell death.

One of the most significant functions of HADHB is its ability to regulate oxygenation. Oxygen is essential for the survival and proper functioning of all cells, and HADHB plays a critical role in regulating the availability of oxygen in cells. In fact, HADHB is shown to be involved in the regulation of oxygen transport in the blood vessels, which is critical for delivering oxygen to the body's tissues.

HADHB is also involved in the regulation of cell growth and cell death. Its C-terminal domain is known to be involved in the regulation of cell adhesion, which is critical for the growth and development of tissues. HADHB is also shown to be involved in the regulation of cell death, as it has been shown to play a role in the programmed cell death that occurs in response to various cellular stressors, including exposure to radiation or chemicals.

In addition to its role in regulating oxygenation and cell growth, HADHB is also involved in the regulation of other cellular processes that are critical for the survival and proper functioning of tissues. For example, it is shown to play a role in the regulation of ion homeostasis, which is critical for the proper functioning of cells and tissues.

HADHB is also involved in the regulation of various signaling pathways that are critical for the survival and proper functioning of tissues. For example, it is shown to play a role in the regulation of the Wnt signaling pathway, which is critical for the development and growth of tissues. HADHB is also shown to play a role in the regulation of theNotch signaling pathway, which is critical for the regulation of cell growth and differentiation.

As a potential drug target, HADHB has been shown to have a variety of potential therapeutic applications. For example, it has been shown to play a role in the regulation of cancer cell growth and has been shown to be involved in the development of various types of cancer, including lung cancer and neurodegenerative diseases. In addition, HADHB has been shown to play a role in the regulation of neurodegenerative diseases, including Alzheimer's disease and Parkinson's disease.

HADHB is also shown to play a role in the regulation of respiratory disorders, including chronic obstructive pulmonary disease (COPD) and asthma. Its ability to regulate oxygenation and cell growth has been shown to play a

Protein Name: Hydroxyacyl-CoA Dehydrogenase Trifunctional Multienzyme Complex Subunit Beta

Functions: Mitochondrial trifunctional enzyme catalyzes the last three of the four reactions of the mitochondrial beta-oxidation pathway (PubMed:8135828, PubMed:29915090, PubMed:30850536). The mitochondrial beta-oxidation pathway is the major energy-producing process in tissues and is performed through four consecutive reactions breaking down fatty acids into acetyl-CoA (PubMed:29915090). Among the enzymes involved in this pathway, the trifunctional enzyme exhibits specificity for long-chain fatty acids (PubMed:30850536). Mitochondrial trifunctional enzyme is a heterotetrameric complex composed of two proteins, the trifunctional enzyme subunit alpha/HADHA carries the 2,3-enoyl-CoA hydratase and the 3-hydroxyacyl-CoA dehydrogenase activities, while the trifunctional enzyme subunit beta/HADHB described here bears the 3-ketoacyl-CoA thiolase activity (PubMed:8135828, PubMed:29915090, PubMed:30850536)

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